{"type":"trials","record":{"id":41,"source_id":"clinicaltrials-gov","external_id":"NCT00891696","title":"Nutritional and Contractile Regulation of Muscle Growth","brief_summary":"Muscle wasting, which involves the loss of muscle tissue, is common in many conditions, such as cancer, AIDS, trauma, kidney failure, bone fracture, and sepsis. It is also prevalent among the elderly and in people who experience periods of physical inactivity and weightlessness. Muscle wasting can lead to overall weakness, immobility, physical dependence, and a greater risk of death when exposed to infection, surgery, or trauma. There is a need to develop scientifically based treatments that prevent muscle wasting. As one step towards such a goal, this study will examine the physiological and cellular mechanisms that regulate skeletal muscle growth.","overall_status":"Completed","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"The University of Texas Medical Branch, Galveston","enrollment":144,"countries":["United States"],"start_date":"2009-04-01","completion_date":"2015-03-01","last_update_date":"2017-05-04","source_url":"https://clinicaltrials.gov/study/NCT00891696","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:44:58.543517+00:00","last_seen_at":"2026-09-25T06:00:07.808+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years to 85 Years","comparator":"Exp 1: AA + Rap; Exp 1: AA; Exp 1: HEx + Rap; Exp 1: HEx; Exp 1: HEx + AA + Rap; Exp 1: HEx + AA; Exp 2: LExFR + Rap; Exp 2 and 3: LExFR","organization":"The University of Texas Medical Branch, Galveston","interventions":["Rapamycin","Amino acid supplementation","Low-intensity resistance exercise","Sodium nitroprusside","Blood flow restriction cuff"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Muscle protein synthesis — Measured during the 8-hour infusion study","Phosphorylation status of mTOR signaling proteins — Measured during the 8-hour infusion study"],"design_description":"RANDOMIZED · FACTORIAL · BASIC SCIENCE · DOUBLE","source_has_results":false},"controlled_terms":["Sarcopenia","Rapamycin","Amino acid supplementation","Low-intensity resistance exercise","Sodium nitroprusside","Blood flow restriction cuff"],"relevance_confidence":62,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Source terminology contains: rapamycin.","quality_checked_at":"2026-09-25T06:00:15.557161+00:00","duplicate_cluster_key":"id:nct00891696","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2009-04-01 to 2015-03-01","comparator":"Exp 1: AA + Rap; Exp 1: AA; Exp 1: HEx + Rap; Exp 1: HEx; Exp 1: HEx + AA + Rap; Exp 1: HEx + AA; Exp 2: LExFR + Rap; Exp 2 and 3: LExFR","confidence":"structured-source","population":"ALL · 18 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:00:07.888Z","intervention":["Rapamycin","Amino acid supplementation","Low-intensity resistance exercise","Sodium nitroprusside","Blood flow restriction cuff"],"participants":144,"study_design":"RANDOMIZED · FACTORIAL · BASIC SCIENCE · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Muscle protein synthesis — Measured during the 8-hour infusion study","Phosphorylation status of mTOR signaling proteins — Measured during the 8-hour infusion study"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"rapamycin","is_published":true,"match_reasons":["Source terminology contains: rapamycin.","Abstract supplies longevity context: elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","abstract context","study type"],"relevance_score":62,"intelligence_topics":{"name":"Rapamycin","slug":"rapamycin"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}