{"type":"trials","record":{"id":41199,"source_id":"clinicaltrials-gov","external_id":"NCT02132715","title":"KAATSU Training to Enhance Physical Function of Older Adults With Osteoarthritis","brief_summary":"As the U.S. population ages and the prevalence of osteoarthritis (OA) among older adults rises, the prevention of OA-associated disability is an important public health priority. Accordingly, efficacious interventions are needed to manage pain and maintain physical function among older adults with OA. Because skeletal muscle weakness is a primary contributory factor to the progression of pain and functional decline among persons with OA, optimal interventions are those capable of improving skeletal muscle strength. High-intensity resistance exercise is the best-known method of improving muscle strength; however high-compressive loads typically induce significant joint pain among persons with OA. Accordingly, current recommendations include the performance of low- or moderate-intensity physical exercise - despite the fact that these training paradigms are sub-optimal for enhancing muscle strength. This application proposes conduct a pilot study to investigate the potential of an innovative training paradigm with potential to stimulate improvements in skeletal muscle strength while utilizing low-intensity loads. This paradigm, known as KAATSU training, involves performing low-intensity exercise while externally-applied compression mildly restricts blood flow to the active skeletal muscle. The overarching objective of the present application is to evaluate the efficacy and feasibility of chronic KAATSU training for the improvement of skeletal muscle strength and physical function among persons aged \\> 60 years with symptomatic knee OA and mild to moderate physical limitations. Up to 72 participants will be recruited to participate in this three month intervention study. Participants will be randomly assigned to one of two intervention conditions: (1) a standard exercise intervention consisting of center-based, moderate-intensity resistance training, or (2) a KAATSU training program matched for overall workload. This study will provide novel information regarding the therapeutic potential of KAATSU training for improving strength and function as well as attenuating pain among these individuals. The study will also provide critical information regarding the long-term, clinical viability of the paradigm by evaluating participant safety, discomfort, and willingness to continually engage in the KAATSU training program.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Florida","enrollment":35,"countries":["United States"],"start_date":"2014-09-01","completion_date":"2016-07-01","last_update_date":"2016-08-23","source_url":"https://clinicaltrials.gov/study/NCT02132715","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:26.536053+00:00","last_seen_at":"2026-09-25T05:35:07.553+00:00","metadata":{"sex":"ALL","acronym":"KAATSU-OA","age_range":"60 Years","comparator":"Resistance exercise","organization":"University of Florida","interventions":["Resistance Exercise","KAATSU exercise"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in isokinetic muscle strength — 6 weeks post-randomization, 12 weeks post-randomization","Change in Short Physical Performance Battery score — 12-weeks post-randomization","Change in self-paced walking speed — 6 weeks-post randomization, 12 weeks post-randomization","Change in Late Life Disability Questionnaire score — 12 weeks post-randomization","Change in Western Ontario and McMaster Osteoarthritis Index score — 12 weeks post-randomization"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","source_has_results":false},"controlled_terms":["Knee Osteoarthritis","Resistance Exercise","KAATSU exercise"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: osteoarthritis.","quality_checked_at":"2026-09-25T05:35:12.977559+00:00","duplicate_cluster_key":"id:nct02132715","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2014-09-01 to 2016-07-01","comparator":"Resistance exercise","confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T05:35:07.577Z","intervention":["Resistance Exercise","KAATSU exercise"],"participants":35,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in isokinetic muscle strength — 6 weeks post-randomization, 12 weeks post-randomization","Change in Short Physical Performance Battery score — 12-weeks post-randomization","Change in self-paced walking speed — 6 weeks-post randomization, 12 weeks post-randomization","Change in Late Life Disability Questionnaire score — 12 weeks post-randomization","Change in Western Ontario and McMaster Osteoarthritis Index score — 12 weeks post-randomization"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"joint-cartilage-aging","is_published":true,"match_reasons":["Title contains controlled term: osteoarthritis.","Abstract contains controlled term: osteoarthritis.","Source terminology contains: osteoarthritis.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Joint and cartilage ageing","slug":"joint-cartilage-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41199","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}