{"type":"trials","record":{"id":41291,"source_id":"clinicaltrials-gov","external_id":"NCT00421681","title":"Exercise Adherence Among Older Adults With Osteoarthritis","brief_summary":"The purpose of this study is to assess the comparative effects of two different ways of enhancing long-term adherence to and benefits associated with participation in the evidence-based, Fit and Strong multi-component exercise intervention for older persons with lower extremity osteoarthritis.","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"National Institute on Aging (NIA)","enrollment":600,"countries":["United States"],"start_date":"2003-10-01","completion_date":"2008-09-01","last_update_date":"2009-12-14","source_url":"https://clinicaltrials.gov/study/NCT00421681","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:26.536053+00:00","last_seen_at":"2026-09-25T05:35:07.553+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years","comparator":null,"organization":"National Institute on Aging (NIA)","interventions":["Fit and Strong! Exercise Program"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Maintenance of exercise behavior measured by CHAMPS (Community Healthy Activities Model Program For Seniors) — Baseline…","Changes in lower extremity strength (timed sit-stand test) — Baseline, 2 months, 6 months, 12 months, 18 months","Aerobic capacity (6 minute distance walk) — Baseline, 2 months, 6 months, 12 months, 18 months","Pain, stiffness, physical function subscales measured by WOMAC (Western Ontario and McMaster osteoarthritis index) — Ba…","Functional ability measured by GeriAIMS (Geriatric Arthritis Impact Measurement Scale) — Baseline, 2 months, 6 months,…"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · NONE","source_has_results":false},"controlled_terms":["Osteoarthritis","Fit and Strong! Exercise Program"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Title contains controlled term: osteoarthritis.","quality_checked_at":"2026-09-25T05:35:12.977559+00:00","duplicate_cluster_key":"id:nct00421681","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2003-10-01 to 2008-09-01","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T05:35:07.589Z","intervention":["Fit and Strong! Exercise Program"],"participants":600,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Maintenance of exercise behavior measured by CHAMPS (Community Healthy Activities Model Program For Seniors) — Baseline…","Changes in lower extremity strength (timed sit-stand test) — Baseline, 2 months, 6 months, 12 months, 18 months","Aerobic capacity (6 minute distance walk) — Baseline, 2 months, 6 months, 12 months, 18 months","Pain, stiffness, physical function subscales measured by WOMAC (Western Ontario and McMaster osteoarthritis index) — Ba…","Functional ability measured by GeriAIMS (Geriatric Arthritis Impact Measurement Scale) — Baseline, 2 months, 6 months,…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"joint-cartilage-aging","is_published":true,"match_reasons":["Title contains controlled term: osteoarthritis.","Abstract contains controlled term: osteoarthritis.","Source terminology contains: osteoarthritis.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Joint and cartilage ageing","slug":"joint-cartilage-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41291","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}