{"type":"trials","record":{"id":414,"source_id":"clinicaltrials-gov","external_id":"NCT05004220","title":"Effects of Plasmapheresis on Aging Biomarkers","brief_summary":"The aim of the study is to evaluate the effect of plasmapheresis (repeated plasma withdrawals) on selected health indicators (hematological, biochemical, immunological and indicators of biological age) of plasma donors.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Charles University, Czech Republic","enrollment":41,"countries":["Czechia"],"start_date":"2021-04-06","completion_date":"2023-02-10","last_update_date":"2023-09-06","source_url":"https://clinicaltrials.gov/study/NCT05004220","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:04.314999+00:00","last_seen_at":"2026-09-15T00:18:35.721+00:00","metadata":{"acronym":null,"organization":"Charles University, Czech Republic","source_has_results":false},"controlled_terms":[],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Published automatically with 80% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct05004220","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"plasma-exchange","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["title"],"relevance_score":80,"intelligence_topics":{"name":"Plasma exchange","slug":"plasma-exchange"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/414","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}