{"type":"trials","record":{"id":41420,"source_id":"clinicaltrials-gov","external_id":"NCT06619405","title":"AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance","brief_summary":"The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark adaptation and reading performance under dim illumination, both which depend on rod photoreceptors.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Duke University","enrollment":100,"countries":["United States"],"start_date":"2025-08-15","completion_date":"2028-01-31","last_update_date":"2026-08-10","source_url":"https://clinicaltrials.gov/study/NCT06619405","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years to 89 Years","comparator":null,"organization":"Duke University","interventions":["Streetlab VR"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Total number of participants with total ellipsoid zone (EZ) band attenuation — Approximately 2 years","Total number of participants with partial ellipsoid zone (EZ) band attenuation — Approximately 2 years","Rod-mediated dark adaptation — Single visit, approximately 5-6 hours","Reading performance as measured by the MNREAD (Minnesota low vision reading) chart — Single visit, approximately 5-6 ho…","Mobility as measured by the Mobility Standardized Test (MOST) — Single visit, approximately 5-6 hours"],"design_description":"NON RANDOMIZED · SINGLE GROUP · DIAGNOSTIC · NONE","source_has_results":false},"controlled_terms":["Age-Related Macular Degeneration","Streetlab VR"],"relevance_confidence":62,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct06619405","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-08-15 to 2028-01-31","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years to 89 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.809Z","intervention":["Streetlab VR"],"participants":100,"study_design":"NON RANDOMIZED · SINGLE GROUP · DIAGNOSTIC · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Total number of participants with total ellipsoid zone (EZ) band attenuation — Approximately 2 years","Total number of participants with partial ellipsoid zone (EZ) band attenuation — Approximately 2 years","Rod-mediated dark adaptation — Single visit, approximately 5-6 hours","Reading performance as measured by the MNREAD (Minnesota low vision reading) chart — Single visit, approximately 5-6 ho…","Mobility as measured by the Mobility Standardized Test (MOST) — Single visit, approximately 5-6 hours"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","abstract context","study type"],"relevance_score":62,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41420","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}