{"type":"trials","record":{"id":41442,"source_id":"clinicaltrials-gov","external_id":"NCT06381596","title":"Retinal Fundus Flavoprotein Fluorescence in Age Related Macular Degeneration","brief_summary":"The goal of this clinical trial is to learn if the areas of stressed cells in the retina correlate to areas of disease identified in standard imaging and whether the images are helpful to identify potential areas of concern before symptoms or disease occurs. The main question it aims to answer is: * to evaluate patterns of increased autofluorescence FPF in the setting of geographic atrophy Participants will undergo FPF imaging using the OcuMet Beacon system.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Wisconsin, Madison","enrollment":32,"countries":["United States"],"start_date":"2024-04-16","completion_date":"2025-05-27","last_update_date":"2026-07-29","source_url":"https://clinicaltrials.gov/study/NCT06381596","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"FPF in AMD","age_range":"50 Years","comparator":null,"organization":"University of Wisconsin, Madison","interventions":["OcuMet Beacon"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Optical Coherence Tomography (OCT) Variables — up to 45 minutes","Flavoprotein Fluorescence (FPF) Intensity — Up to 45 minutes","FPF Heterogeneity — up to 45 minutes","Correlation Between FPF-intensity, FPF-heterogeneity and OCT Continuous Variables — up to 45 minutes","Compare the Cross-sectional Associations Between FPF Intensity to FAF Area at the Time of Measurement — Up to 45 minutes","Compare the Cross-sectional Associations Between Best Corrected Visual Acuity (BCVA - Using Early Treatment Diabetic Re…","Correlation Between FPF-intensity, FPF-heterogeneity and Participant Variables — up to 45 minutes"],"design_description":"NA · SINGLE GROUP · OTHER · NONE","source_has_results":true},"controlled_terms":["Geographic Atrophy","Age-Related Macular Degeneration","OcuMet Beacon"],"relevance_confidence":62,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct06381596","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-04-16 to 2025-05-27","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.813Z","intervention":["OcuMet Beacon"],"participants":32,"study_design":"NA · SINGLE GROUP · OTHER · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Optical Coherence Tomography (OCT) Variables — up to 45 minutes","Flavoprotein Fluorescence (FPF) Intensity — Up to 45 minutes","FPF Heterogeneity — up to 45 minutes","Correlation Between FPF-intensity, FPF-heterogeneity and OCT Continuous Variables — up to 45 minutes","Compare the Cross-sectional Associations Between FPF Intensity to FAF Area at the Time of Measurement — Up to 45 minutes","Compare the Cross-sectional Associations Between Best Corrected Visual Acuity (BCVA - Using Early Treatment Diabetic Re…","Correlation Between FPF-intensity, FPF-heterogeneity and Participant Variables — up to 45 minutes"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","abstract context","study type"],"relevance_score":62,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41442","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}