{"type":"trials","record":{"id":41454,"source_id":"clinicaltrials-gov","external_id":"NCT06237127","title":"Effects of Goji vs. Fiber on Macular Degeneration","brief_summary":"The goal of this project is to conduct a clinical trial in 60 participants ranging from age 65-95 who are at risk for age-related macular degeneration (AMD). The study will evaluate the effects of 14g of goji berry intake or an equivalent amount and type of fiber, five days a week for six months, on visual health, gut microbiome profiles, skin carotenoid measures, and lipoprotein profiles.","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of California, Davis","enrollment":60,"countries":["United States"],"start_date":"2024-04-29","completion_date":"2027-12-31","last_update_date":"2026-07-17","source_url":"https://clinicaltrials.gov/study/NCT06237127","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"GOJI","age_range":"65 Years to 95 Years","comparator":"Fiber","organization":"University of California, Davis","interventions":["Goji berry","Fiber"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Macular pigment optical volume (MPOV) — Day 0 and Day 180","Stool microbiome — Day 0 and Day 180","Spectral Domain-Ocular Coherence Tomography (SD-OCT) — Day 0 and Day 180","Fundus autofluorescence (FAF) — Day 0 and Day 180","Color Fundus Photography (CFP) — Day 0 and Day 180","Microperimetry testing — Day 0 and Day 180","Dark adaptometry — Day 0 and Day 180","Plasma microbial metabolites — Day 0 and Day 180","Plasma lutein and zeaxanthin — Day 0 and Day 180","Lipoprotein profile — Day 0 and Day 180","HDL particle characteristics — Day 0 and Day 180","Peripheral blood mononuclear cells (PBMC) gene expression changes — Day 0 and Day 180","Cognitive function — Day 0 and Day 180","Handgrip strength — Day 0 and Day 180"],"design_description":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · NONE","source_has_results":false},"controlled_terms":["Age-Related Macular Degeneration","Goji berry","Fiber"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct06237127","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-04-29 to 2027-12-31","comparator":"Fiber","confidence":"structured-source","population":"ALL · 65 Years to 95 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.815Z","intervention":["Goji berry","Fiber"],"participants":60,"study_design":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Macular pigment optical volume (MPOV) — Day 0 and Day 180","Stool microbiome — Day 0 and Day 180","Spectral Domain-Ocular Coherence Tomography (SD-OCT) — Day 0 and Day 180","Fundus autofluorescence (FAF) — Day 0 and Day 180","Color Fundus Photography (CFP) — Day 0 and Day 180","Microperimetry testing — Day 0 and Day 180","Dark adaptometry — Day 0 and Day 180","Plasma microbial metabolites — Day 0 and Day 180","Plasma lutein and zeaxanthin — Day 0 and Day 180","Lipoprotein profile — Day 0 and Day 180","HDL particle characteristics — Day 0 and Day 180","Peripheral blood mononuclear cells (PBMC) gene expression changes — Day 0 and Day 180","Cognitive function — Day 0 and Day 180","Handgrip strength — Day 0 and Day 180"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41454","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}