{"type":"trials","record":{"id":41461,"source_id":"clinicaltrials-gov","external_id":"NCT07024732","title":"A Safety and Tolerability Clinical Trial of PST-611 in Dry Age-related Macular Degeneration","brief_summary":"The goal of this interventional study is to evaluate the safety and tolerability of single ascending doses of PST-611 in men and women over the age of 50 with dry age-related macular degeneration (AMD). The main question it aims to answer is: Is PST-611-CT1 safe for participants? Participants will: * Receive a single dose of PST-611 * Will be followed up for a total of 16 weeks following PST-611 administration","overall_status":"Completed","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Eyevensys","enrollment":8,"countries":["France"],"start_date":"2025-06-23","completion_date":"2026-04-07","last_update_date":"2026-07-13","source_url":"https://clinicaltrials.gov/study/NCT07024732","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years","comparator":null,"organization":"Eyevensys","interventions":["PST-611"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Safety and Tolerability — Screening to week 16","Intraocular pressure — Screening to Week 16","Best corrected visual acuity — Screening to Week 16","Slit lamp biomicroscopy examination — Screening to Week 16","Dilated ophthalmoscopy examination — Screening to Week 16","Color fundus photography — Screening to Week 16","Spectral Domain-Optical Coherence Tomography — Screening to Week 16"],"design_description":"NA · SEQUENTIAL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Dry Age Related Macular Degeneration","PST-611"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct07024732","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-06-23 to 2026-04-07","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.817Z","intervention":["PST-611"],"participants":8,"study_design":"NA · SEQUENTIAL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Safety and Tolerability — Screening to week 16","Intraocular pressure — Screening to Week 16","Best corrected visual acuity — Screening to Week 16","Slit lamp biomicroscopy examination — Screening to Week 16","Dilated ophthalmoscopy examination — Screening to Week 16","Color fundus photography — Screening to Week 16","Spectral Domain-Optical Coherence Tomography — Screening to Week 16"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41461","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}