{"type":"trials","record":{"id":41479,"source_id":"clinicaltrials-gov","external_id":"NCT07004361","title":"Ethical Issues of Using Gene Therapy in the Treatment of AMD","brief_summary":"The objective of this study is to examine the legitimacy of gene therapy use in the treatment of exudative age-related macular degeneration (AMD). This involves questioning its beneficence/non-maleficence ratio given the limited experience with this innovative technology and its irreversible effects, requiring a surgical procedure for administration. Additionally, the study explores patient autonomy in decision-making concerning complex therapeutic approaches and how patients should be supported to best uphold this autonomy.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Nantes University Hospital","enrollment":30,"countries":["France"],"start_date":"2025-07-01","completion_date":"2026-12-01","last_update_date":"2026-06-24","source_url":"https://clinicaltrials.gov/study/NCT07004361","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":null,"organization":"Nantes University Hospital","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["The experience and current treatment outcomes perceived by patients — 1 months","Patients' perceptions, expectations, and potential concerns regarding gene therapy — 1 month","Patients' perception and representation of decisional autonomy in their health decisions — 1 month"],"design_description":null,"source_has_results":false},"controlled_terms":["Exudative Age-related Macular Degeneration"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct07004361","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-07-01 to 2026-12-01","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.819Z","intervention":[],"participants":30,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["The experience and current treatment outcomes perceived by patients — 1 months","Patients' perceptions, expectations, and potential concerns regarding gene therapy — 1 month","Patients' perception and representation of decisional autonomy in their health decisions — 1 month"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41479","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}