{"type":"trials","record":{"id":41512,"source_id":"clinicaltrials-gov","external_id":"NCT07021027","title":"Eggs and Age-related Macular Degeneration (EggsAMD) Study.","brief_summary":"Age-related macular degeneration (AMD) is the primary cause of vision loss in people over the age of 55. Currently, no cure is available for individuals suffering from AMD. The purpose of this pilot study is to evaluate the feasibility of implementing a 5-month egg intervention in adults with intermediate AMD. The objective of this research study is to evaluate the feasibility of a whole egg (2 or 4 per day) intervention in older adults with intermediate AMD. The secondary objective of this research is to determine descriptive statistics, change over time and estimate effect sizes for retinal sensitivity, and vision, cognition and physical function. By completing these research objectives, the researchers hope to gain preliminary evidence in support of a larger trial that will assess the impact of egg consumption on eye health in adults with AMD.","overall_status":"Active Not Recruiting","phases":["EARLY_PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Kathryn Starr","enrollment":19,"countries":["United States"],"start_date":"2025-06-18","completion_date":"2026-10-31","last_update_date":"2026-05-28","source_url":"https://clinicaltrials.gov/study/NCT07021027","editorial_summary":"A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"EggsAMD","age_range":"55 Years","comparator":"Whole Egg - 2","organization":"Duke University","interventions":["Whole Egg - 4","Whole Egg - 2"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Adherence rate to consuming four whole eggs per day — From intervention start to the end of treatment at 5 months.","Vision function, as measured by percent reduced threshold (PRT) — Baseline and 5 months","Vision function, as measured by Average threshold (AT) — Baseline and 5 months","Vision function, as measured by Central macular thickness — Baseline and 5 months","Vision function, as measured by Best Corrected Visual Acuity (BCVA) — Baseline and 5 months","Vision function, as measured by Low Luminance Visual Acuity (LL-BCVA) — Baseline and 5 months","Vision function, as measured by Reading Acuity (MN Read) — Baseline and 5 months","Vision function, as measured by Contrast Sensitivity — Baseline and 5 months","Vision function, as measured by National Eye Institute Visual Functioning Questionnaire - 25 (VFQ-25) — Baseline and 5…","Cognitive function, as measured by the Hopkins Verbal Learning Test — Baseline and 5 months","Physical Function, as measured by balance — Baseline and 5 months","Physical Function, as measured by 30-Second Chair Stand — Baseline and 5 months","Physical Function, as measured by 30-Second Arm curl — Baseline and 5 months","Physical Function, as measured by 8-foot up and go — Baseline and 5 months","Quality of Life, as measured by the 36-Item Short Form Health Survey (SF-36) — Baseline and 5 months","Dietary Intake — Baseline and 5 months","Satisfaction with study participation — From enrollment to the end of treatment at 5 months","Satisfaction with egg consumption (Whole Egg - 2) — From intervention start to the end of treatment at 5 months.","Satisfaction with egg consumption (Whole Egg - 4) — From intervention start to the end of treatment at 5 months."],"design_description":"RANDOMIZED · PARALLEL · OTHER · DOUBLE","source_has_results":false},"controlled_terms":["Intermediate Age-Related Macular Degeneration","Whole Egg - 4","Whole Egg - 2"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct07021027","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-06-18 to 2026-10-31","comparator":"Whole Egg - 2","confidence":"structured-source","population":"ALL · 55 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.825Z","intervention":["Whole Egg - 4","Whole Egg - 2"],"participants":19,"study_design":"RANDOMIZED · PARALLEL · OTHER · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"EARLY_PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Adherence rate to consuming four whole eggs per day — From intervention start to the end of treatment at 5 months.","Vision function, as measured by percent reduced threshold (PRT) — Baseline and 5 months","Vision function, as measured by Average threshold (AT) — Baseline and 5 months","Vision function, as measured by Central macular thickness — Baseline and 5 months","Vision function, as measured by Best Corrected Visual Acuity (BCVA) — Baseline and 5 months","Vision function, as measured by Low Luminance Visual Acuity (LL-BCVA) — Baseline and 5 months","Vision function, as measured by Reading Acuity (MN Read) — Baseline and 5 months","Vision function, as measured by Contrast Sensitivity — Baseline and 5 months","Vision function, as measured by National Eye Institute Visual Functioning Questionnaire - 25 (VFQ-25) — Baseline and 5…","Cognitive function, as measured by the Hopkins Verbal Learning Test — Baseline and 5 months","Physical Function, as measured by balance — Baseline and 5 months","Physical Function, as measured by 30-Second Chair Stand — Baseline and 5 months","Physical Function, as measured by 30-Second Arm curl — Baseline and 5 months","Physical Function, as measured by 8-foot up and go — Baseline and 5 months","Quality of Life, as measured by the 36-Item Short Form Health Survey (SF-36) — Baseline and 5 months","Dietary Intake — Baseline and 5 months","Satisfaction with study participation — From enrollment to the end of treatment at 5 months","Satisfaction with egg consumption (Whole Egg - 2) — From intervention start to the end of treatment at 5 months.","Satisfaction with egg consumption (Whole Egg - 4) — From intervention start to the end of treatment at 5 months."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41512","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}