{"type":"trials","record":{"id":41518,"source_id":"clinicaltrials-gov","external_id":"NCT07328776","title":"AI vs. Physician for Anti-VEGF Decision-Making: An RCT","brief_summary":"We developed an artificial intelligence system, called QiLin, which was designed to assist anti-VEGF treatment decisions in retinal diseases. QiLin was trained and validated via over 20,000 optical coherence tomography images from multicenter datasets, demonstrating strong performance on both internal and external validation. To evaluate its real-world clinical utility, we conducted a randomized controlled trial that rigorously compares the accuracy of treatment decisions between a physician-only arm and an AI-assisted physician arm.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","enrollment":200,"countries":["China"],"start_date":"2026-05-25","completion_date":"2026-10-15","last_update_date":"2026-05-22","source_url":"https://clinicaltrials.gov/study/NCT07328776","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years to 85 Years","comparator":"physician only arm","organization":"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","interventions":["QiLin-assisted","physician only, without QiLin assisted"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Accuracy of the current anti-VEGF injection decision — At enrollment","Accuracy of detecting active biomarkers on the current OCT image — At enrollment"],"design_description":"RANDOMIZED · PARALLEL · OTHER · DOUBLE","source_has_results":false},"controlled_terms":["DME","Retinal Vein Occlusion (RVO)","Neovascular (Wet) Age-Related Macular Degeneration","QiLin-assisted","physician only, without QiLin assisted"],"relevance_confidence":60,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct07328776","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-05-25 to 2026-10-15","comparator":"physician only arm","confidence":"structured-source","population":"ALL · 50 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.826Z","intervention":["QiLin-assisted","physician only, without QiLin assisted"],"participants":200,"study_design":"RANDOMIZED · PARALLEL · OTHER · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Accuracy of the current anti-VEGF injection decision — At enrollment","Accuracy of detecting active biomarkers on the current OCT image — At enrollment"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Source terminology supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","controlled context","study type"],"relevance_score":60,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41518","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}