{"type":"trials","record":{"id":41538,"source_id":"clinicaltrials-gov","external_id":"NCT05355415","title":"Adaptive Optics Imaging of Outer Retinal Diseases","brief_summary":"The objective of the study is to collect adaptive optics (AO) retinal images from human subjects with outer retinal diseases (diseases of the outer retina including photoreceptor, retinal pigment epithelium (RPE), basement membrane or choroidal pathologies) to develop new diagnostic methods, biomarkers, and clinical endpoints.","overall_status":"Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Food and Drug Administration (FDA)","enrollment":100,"countries":["United States"],"start_date":"2021-08-27","completion_date":"2028-09-30","last_update_date":"2026-05-08","source_url":"https://clinicaltrials.gov/study/NCT05355415","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"21 Years","comparator":null,"organization":"Food and Drug Administration (FDA)","interventions":["Adaptive optics imaging"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Photoreceptor (PR) density — PR density will be calculated once at the AO imaging session in which PRs are the target.","Retinal pigment epithelial (RPE) cell density — RPE cell density will be calculated once at the AO imaging session in w…","RPE cell organelle motility — RPE motility will be calculated once at the AO imaging session in which RPE cells are the…","PR cell function — PR function will be calculated once at the AO imaging session in which PR cells are stimulated. For…"],"design_description":null,"source_has_results":false},"controlled_terms":["Retinal Degeneration","Age-Related Macular Degeneration","Retinitis Pigmentosa","Hydroxychloroquine Retinopathy","Usher Syndromes","Late-Onset Retinal Degeneration","Cone Dystrophy","Cone Rod Dystrophy","Rod Cone Dystrophy","Rod Dystrophy","Adaptive optics imaging"],"relevance_confidence":70,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct05355415","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-08-27 to 2028-09-30","comparator":null,"confidence":"structured-source","population":"ALL · 21 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.829Z","intervention":["Adaptive optics imaging"],"participants":100,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Photoreceptor (PR) density — PR density will be calculated once at the AO imaging session in which PRs are the target.","Retinal pigment epithelial (RPE) cell density — RPE cell density will be calculated once at the AO imaging session in w…","RPE cell organelle motility — RPE motility will be calculated once at the AO imaging session in which RPE cells are the…","PR cell function — PR function will be calculated once at the AO imaging session in which PR cells are stimulated. For…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Title supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["controlled terminology","title context","study type"],"relevance_score":70,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41538","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}