{"type":"trials","record":{"id":41543,"source_id":"clinicaltrials-gov","external_id":"NCT07567898","title":"Effectiveness of Multidisciplinary Protocolised Interventions on IVT Non-adherence Rates","brief_summary":"The purpose of this research study is to test whether a personalised care approach improves adherence compared to standard care. Many patients with macular diseases like age-related macular degeneration and diabetic macular edema need regular eye injections to protect their vision. However, some do not adhere to their treatment appointments, risking further vision loss. You were selected as a possible participant in this research study because you have been diagnosed with neovascular age-related macular degeneration (nAMD) or diabetic macula edema (DME) requiring intravitreal injection treatment (IVT). This research study targets to recruit 200 participants from the Singapore National Eye Centre. This study comprises two cohort groups: Cohort 1(Suboptimal CAT scores/ Randomized Control trial) and Cohort 2 (Optimal CAT scores/Observation). If you agree to take part in this study, the research coordinator will obtain your written consent before proceeding with the study procedures. You will be required to complete CAT assessment (via remote or administered in clinic) and assigned to cohort 1 or cohort 2 based on CAT scores result. If you are assigned to cohort 1, you will be randomly allocated to either the personalized multi-disciplinary protocolized intervention (MPI) or standard care group. Randomization means assigning you to one of two groups by chance, like tossing a coin or rolling a dice. * MPI group: You will complete a specialized computerized adaptive testing (CAT) quality of life questionnaire. Based on the domain specific scores, you will receive a medical consultation and a referral to nurse educators, optometrists, occupational therapists, or social workers. * Standard care group: If you are allocated to this group, you will receive standard care, where doctors make treatment decisions without using the CAT results. If you are assigned to cohort 2, you will be placed under prospective observation and undergo routine clinical care.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Singapore Eye Research Institute","enrollment":200,"countries":[],"start_date":"2026-04-01","completion_date":"2028-09-01","last_update_date":"2026-05-05","source_url":"https://clinicaltrials.gov/study/NCT07567898","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"ADHERE","age_range":null,"comparator":"Multidisciplinary protocolized intervention (MPI); Standard care","organization":"Singapore Eye Research Institute","interventions":["multidisciplinary protocolized intervention (MPI)","Routine medical care & monitoring"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Effectiveness of multidisciplinary protocolized intervention (MPI) in improving adherence to intravitreal (IVT) Injecti…","Comparison of CAT scores (Specific aim 2A) from the CAT questionnaire database — Baseline, 6,12 and 18 month","Effectiveness of MPI in improvement of visual function — Enrolment to 18 months","Effectiveness of MPI in increasing disease-free intervals in patients with nAMD or DME receiving IVT and having subopti…","The implementation outcomes of MPI through mixed method testing with interviews and questionnaires (Specific aim 3). —…","To assess the cost-effectiveness of the MPI for improving adherence to IVT, considering its potential impact on long te…"],"design_description":"RANDOMIZED · PARALLEL · HEALTH SERVICES RESEARCH · DOUBLE","source_has_results":false},"controlled_terms":["Diabetic Macular Edema","Neovascular (Wet) Age-Related Macular Degeneration","Intravitreal Injection","multidisciplinary protocolized intervention (MPI)","Routine medical care & monitoring"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct07567898","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2026-04-01 to 2028-09-01","comparator":"Multidisciplinary protocolized intervention (MPI); Standard care","confidence":"structured-source","population":"ALL","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.831Z","intervention":["multidisciplinary protocolized intervention (MPI)","Routine medical care & monitoring"],"participants":200,"study_design":"RANDOMIZED · PARALLEL · HEALTH SERVICES RESEARCH · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Effectiveness of multidisciplinary protocolized intervention (MPI) in improving adherence to intravitreal (IVT) Injecti…","Comparison of CAT scores (Specific aim 2A) from the CAT questionnaire database — Baseline, 6,12 and 18 month","Effectiveness of MPI in improvement of visual function — Enrolment to 18 months","Effectiveness of MPI in increasing disease-free intervals in patients with nAMD or DME receiving IVT and having subopti…","The implementation outcomes of MPI through mixed method testing with interviews and questionnaires (Specific aim 3). —…","To assess the cost-effectiveness of the MPI for improving adherence to IVT, considering its potential impact on long te…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41543","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}