{"type":"trials","record":{"id":41547,"source_id":"clinicaltrials-gov","external_id":"NCT05904691","title":"Safety and Tolerability of OCU-10-C-110 for Injection in Subjects With Neovascular Age-related Macular Degeneration","brief_summary":"Multi-center, open-label, two-part safety assessment following administration of single ascending doses and repeat administration of the HTD of OCU-10-C-110 for Injection in the study eye of participants with nAMD","overall_status":"Active Not Recruiting","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Ocugenix Corporation","enrollment":24,"countries":["United States"],"start_date":"2023-11-01","completion_date":"2026-11-30","last_update_date":"2026-05-01","source_url":"https://clinicaltrials.gov/study/NCT05904691","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years","comparator":null,"organization":"Ocugenix Corporation","interventions":["OCU-10-C-110 for Injection"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Ocular safety - AE — Cohort A - 8 weeks; Cohort B - 12 weeks","Systemic safety - AE — Cohort A - 8 weeks; Cohort B - 12 weeks"],"design_description":"NON RANDOMIZED · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Neovascular Age-related Macular Degeneration (nAMD)","OCU-10-C-110 for Injection"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct05904691","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-11-01 to 2026-11-30","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.831Z","intervention":["OCU-10-C-110 for Injection"],"participants":24,"study_design":"NON RANDOMIZED · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Ocular safety - AE — Cohort A - 8 weeks; Cohort B - 12 weeks","Systemic safety - AE — Cohort A - 8 weeks; Cohort B - 12 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41547","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}