{"type":"trials","record":{"id":416,"source_id":"clinicaltrials-gov","external_id":"NCT05054894","title":"Plasmapheresis for Treatment of Age-Related Frailty","brief_summary":"This study is designed to evaluate the efficacy of albumin-infused plasmapheresis, using the Fresenius Kabi 'Amicus' apheresis machine, among patients with age-related frailty characterized by reduced physical, cognitive and immunological functioning. Additionally, this study is designed to evaluate the safety and tolerability of repeated plasmapheresis treatment.","overall_status":"Unknown","phases":["EARLY_PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Neurological Associates of West Los Angeles","enrollment":100,"countries":["United States"],"start_date":"2021-03-19","completion_date":"2025-05-01","last_update_date":"2022-04-18","source_url":"https://clinicaltrials.gov/study/NCT05054894","editorial_summary":"A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:04.314999+00:00","last_seen_at":"2026-09-15T00:18:35.721+00:00","metadata":{"acronym":null,"organization":"Neurological Associates of West Los Angeles","source_has_results":false},"controlled_terms":[],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Published automatically with 80% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct05054894","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"plasma-exchange","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["title"],"relevance_score":80,"intelligence_topics":{"name":"Plasma exchange","slug":"plasma-exchange"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/416","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}