{"type":"trials","record":{"id":41601,"source_id":"clinicaltrials-gov","external_id":"NCT06723288","title":"A Study Conducted to Evaluate the Conjunctiva and Tenon's Capsule Status of Healthy Subjects and in Participants With Neovascular Age-related Macular Degeneration (nAMD)/Diabetic Macular Edema (DME)","brief_summary":"The purpose of this study is to obtain conjunctiva and tenon's capsule thickness measurements in vivo using spectral domain-optical coherence tomography (SD-OCT) in participants with nAMD/DME and age-matched healthy subjects.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Hoffmann-La Roche","enrollment":736,"countries":["Spain"],"start_date":"2024-12-31","completion_date":"2025-11-28","last_update_date":"2026-02-27","source_url":"https://clinicaltrials.gov/study/NCT06723288","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"45 Years","comparator":null,"organization":"Hoffmann-La Roche","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Cohorts A and B: Conjunctival Thickness Measured Using SD-OCT — At study visit (Day 1)","Cohorts A and B: Tenon's Capsule Thickness Measured Using SD-OCT — At study visit (Day 1)","Cohorts A and B: Sum of Conjunctival and Tenon's Capsule Measured Using SD-OCT — At study visit (Day 1)","Cohorts A and B: Number of Participants in Age Groups 45-54, 55-64, 65-74, ≥75 Years — At study visit (Day 1)","Cohort A: Previous Intravitreal (IVT) Injections (Yes/No) — At study visit (Day 1)"],"design_description":null,"source_has_results":false},"controlled_terms":["Neovascular Age-related Macular Degeneration","Diabetic Macular Edema"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct06723288","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-12-31 to 2025-11-28","comparator":null,"confidence":"structured-source","population":"ALL · 45 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.839Z","intervention":[],"participants":736,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Cohorts A and B: Conjunctival Thickness Measured Using SD-OCT — At study visit (Day 1)","Cohorts A and B: Tenon's Capsule Thickness Measured Using SD-OCT — At study visit (Day 1)","Cohorts A and B: Sum of Conjunctival and Tenon's Capsule Measured Using SD-OCT — At study visit (Day 1)","Cohorts A and B: Number of Participants in Age Groups 45-54, 55-64, 65-74, ≥75 Years — At study visit (Day 1)","Cohort A: Previous Intravitreal (IVT) Injections (Yes/No) — At study visit (Day 1)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41601","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}