{"type":"trials","record":{"id":41613,"source_id":"clinicaltrials-gov","external_id":"NCT07390253","title":"Switch From 2mg Aflibercept to 8mg Aflibercept in Patients With Neovascular Age-related Macular Degeneration","brief_summary":"This study will investigate if switching patients who appear to be sub-optimal responders to the current standard of care treatment with Aflibercept 2mg to Aflibercept 8mg will prolong treatment intervals and maintain visual acuity.","overall_status":"Active Not Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Vienna Institute for Research in Ocular Surgery","enrollment":50,"countries":["Austria"],"start_date":"2024-09-18","completion_date":"2026-06-01","last_update_date":"2026-02-17","source_url":"https://clinicaltrials.gov/study/NCT07390253","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"21 Years to 105 Years","comparator":null,"organization":"Vienna Institute for Research in Ocular Surgery","interventions":["Aflibercept"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Number of intravitreal injections — 12 months","corrected distance visual acuity (CDVA) — 12 months","Central retinal thickness (CRT) — 12 months","Intraretinal fluid (IRF) — 12 months"],"design_description":null,"source_has_results":false},"controlled_terms":["Neovascular (Wet) Age-Related Macular Degeneration","Aflibercept"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct07390253","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2024-09-18 to 2026-06-01","comparator":null,"confidence":"structured-source","population":"ALL · 21 Years to 105 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.841Z","intervention":["Aflibercept"],"participants":50,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Number of intravitreal injections — 12 months","corrected distance visual acuity (CDVA) — 12 months","Central retinal thickness (CRT) — 12 months","Intraretinal fluid (IRF) — 12 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41613","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}