{"type":"trials","record":{"id":41630,"source_id":"clinicaltrials-gov","external_id":"NCT07375901","title":"the Blood-Aqeous Barrier During Anti-Angiogenic Therapy in Exudative Age-Related Macular Degeneration","brief_summary":"To evaluate the status of the blood-aqueous barrier by objectively measuring protein concentration in the aqueous humor using laser flare photometry (LFP) in patients with exudative age-related macular degeneration (AMD) undergoing anti-angiogenic therapy.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"The Filatov Institute of Eye Diseases and Tissue Therapy","enrollment":30,"countries":["Ukraine"],"start_date":"2021-03-25","completion_date":"2024-04-10","last_update_date":"2026-01-29","source_url":"https://clinicaltrials.gov/study/NCT07375901","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"BABAMD","age_range":"47 Years to 88 Years","comparator":"Group of aflibercept; Group of brolucizumab","organization":"The Filatov Institute of Eye Diseases and Tissue Therapy","interventions":["laser flare photometry before intravitreal injection"],"registry_source":"ClinicalTrials.gov","outcome_measures":["laser flare photometry values in the aqueous humor — 6-month","best-corrected visual acuity — 6-month","central retinal thickness — 6-month"],"design_description":"RANDOMIZED · PARALLEL · DIAGNOSTIC · NONE","source_has_results":false},"controlled_terms":["AMD","laser flare photometry before intravitreal injection"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct07375901","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-03-25 to 2024-04-10","comparator":"Group of aflibercept; Group of brolucizumab","confidence":"structured-source","population":"ALL · 47 Years to 88 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.844Z","intervention":["laser flare photometry before intravitreal injection"],"participants":30,"study_design":"RANDOMIZED · PARALLEL · DIAGNOSTIC · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["laser flare photometry values in the aqueous humor — 6-month","best-corrected visual acuity — 6-month","central retinal thickness — 6-month"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41630","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}