{"type":"trials","record":{"id":41637,"source_id":"clinicaltrials-gov","external_id":"NCT04735263","title":"Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD","brief_summary":"interventional trial for off label use of high dose atorvastatin 80 mg in intermediate AMD patients and correlate recovery response measured by dark adaptation recovery time with drusen volume reduction measured by SD-OCT","overall_status":"Recruiting","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Massachusetts Eye and Ear Infirmary","enrollment":21,"countries":["United States"],"start_date":"2021-02-04","completion_date":"2028-01-01","last_update_date":"2026-01-26","source_url":"https://clinicaltrials.gov/study/NCT04735263","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"DELPHI","age_range":"50 Years to 85 Years","comparator":null,"organization":"Massachusetts Eye and Ear Infirmary","interventions":["Atorvastatin 80mg"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Dark Adaptation recovery time measured by change in Rod Intercept time (RIT) — 18 Months","Change in drusen volume measured by Spectral Domain OCT — 18 months","To correlate visual functions of dark adaption with change in drusen volume — 18 months","To correlate Best Corrected Visual Acuity and retinal structural evaluation of study patients — 18 months","To correlate change in contrast sensitivity and retinal structural evaluation of study patients — 18 months","To correlate change in microperimetry visual functional and retinal structural evaluation of study patients — 18 months"],"design_description":"NA · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Age-related Macular Degeneration","Atorvastatin 80mg"],"relevance_confidence":60,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct04735263","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-02-04 to 2028-01-01","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.845Z","intervention":["Atorvastatin 80mg"],"participants":21,"study_design":"NA · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Dark Adaptation recovery time measured by change in Rod Intercept time (RIT) — 18 Months","Change in drusen volume measured by Spectral Domain OCT — 18 months","To correlate visual functions of dark adaption with change in drusen volume — 18 months","To correlate Best Corrected Visual Acuity and retinal structural evaluation of study patients — 18 months","To correlate change in contrast sensitivity and retinal structural evaluation of study patients — 18 months","To correlate change in microperimetry visual functional and retinal structural evaluation of study patients — 18 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Source terminology supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","controlled context","study type"],"relevance_score":60,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41637","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}