{"type":"trials","record":{"id":41690,"source_id":"clinicaltrials-gov","external_id":"NCT04627428","title":"Safety and Tolerability of RPE Stem Cell-derived RPE(RPESC-RPE) Transplantation in Patients With Dry Age-related Macular Degeneration (AMD)","brief_summary":"The main objective of the study is evaluation of the safety and tolerability of RPESC-RPE-4W as therapy for dry AMD.","overall_status":"Recruiting","phases":["PHASE1","PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Luxa Biotechnology, LLC","enrollment":18,"countries":["United States"],"start_date":"2022-04-05","completion_date":"2026-12-01","last_update_date":"2025-10-15","source_url":"https://clinicaltrials.gov/study/NCT04627428","editorial_summary":"A registered PHASE1, PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"55 Years","comparator":null,"organization":"Luxa Biotechnology, LLC","interventions":["RPESC-RPE-4W"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Safety and tolerability of RPESC-RPE-4W transplantation — 24 months","Change in the mean of Best Corrected Visual Acuity (BCVA) — 24 months","Loss of ≥10 decibels of ten-degree average visual sensitivity microperimetry — 24 months","Change in GA lesion area — 24 months","Evidence of structural changes — 24 months"],"design_description":"NON RANDOMIZED · SEQUENTIAL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Dry Age-related Macular Degeneration","RPESC-RPE-4W"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct04627428","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-04-05 to 2026-12-01","comparator":null,"confidence":"structured-source","population":"ALL · 55 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.854Z","intervention":["RPESC-RPE-4W"],"participants":18,"study_design":"NON RANDOMIZED · SEQUENTIAL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1, PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Safety and tolerability of RPESC-RPE-4W transplantation — 24 months","Change in the mean of Best Corrected Visual Acuity (BCVA) — 24 months","Loss of ≥10 decibels of ten-degree average visual sensitivity microperimetry — 24 months","Change in GA lesion area — 24 months","Evidence of structural changes — 24 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41690","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}