{"type":"trials","record":{"id":41696,"source_id":"clinicaltrials-gov","external_id":"NCT05265624","title":"The Moran AMD Genetic Testing Assessment Study","brief_summary":"The goals of this study are: To assess the impact of genetic testing for Age-related Macular Degeneration (AMD) on lifestyle behaviors as measured by systemic and ocular carotenoid status.","overall_status":"Completed","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Paul S. Bernstein","enrollment":80,"countries":["United States"],"start_date":"2022-08-03","completion_date":"2024-07-12","last_update_date":"2025-10-01","source_url":"https://clinicaltrials.gov/study/NCT05265624","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"MAGENTA","age_range":"18 Years to 64 Years","comparator":"Late Genetic Results Disclosure","organization":"University of Utah","interventions":["Early disclosure of genetic testing results","Late disclosure of genetic testing results"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in Skin Carotenoid Status in Response to Genetic Risk Disclosure as Measured by Reflectance Spectroscopy — Basel…","Change in Skin Carotenoid Status in Response to Genetic Risk Disclosure as Measured by Resonance Raman Spectroscopy — B…","Change in Ocular Carotenoid Status in Response to Genetic Risk Disclosure as Measured by Macular Pigment Optical Volume…","Change in Serum Carotenoid Status in Response to Genetic Risk Disclosure — Baseline and Month 12"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · TRIPLE","source_has_results":true},"controlled_terms":["Age-Related Macular Degeneration","Genetic Testing","Nutritional Biomarkers","Early disclosure of genetic testing results","Late disclosure of genetic testing results"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":85,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct05265624","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-08-03 to 2024-07-12","comparator":"Late Genetic Results Disclosure","confidence":"structured-source","population":"ALL · 18 Years to 64 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.855Z","intervention":["Early disclosure of genetic testing results","Late disclosure of genetic testing results"],"participants":80,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in Skin Carotenoid Status in Response to Genetic Risk Disclosure as Measured by Reflectance Spectroscopy — Basel…","Change in Skin Carotenoid Status in Response to Genetic Risk Disclosure as Measured by Resonance Raman Spectroscopy — B…","Change in Ocular Carotenoid Status in Response to Genetic Risk Disclosure as Measured by Macular Pigment Optical Volume…","Change in Serum Carotenoid Status in Response to Genetic Risk Disclosure — Baseline and Month 12"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41696","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}