{"type":"trials","record":{"id":41705,"source_id":"clinicaltrials-gov","external_id":"NCT05706896","title":"Atrophic Age-related Macular Degeneration Treated With Intravitreal Injections of Umbilical Cord Blood Platelet-rich Plasma","brief_summary":"The objective of the study will be to evaluate the efficacy of intravitreal injections of Umbilical Cord Blood Platelet-rich Plasma (CB-PRP) in order to reduce or stabilize the atrophic progression in dry Age-related Macular Degeneration (AMD)","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","enrollment":36,"countries":["Italy"],"start_date":"2022-12-14","completion_date":"2026-02-10","last_update_date":"2025-09-23","source_url":"https://clinicaltrials.gov/study/NCT05706896","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"CORD-IV","age_range":"65 Years","comparator":null,"organization":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","interventions":["Intravitreal injection of CB-PRP"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Autofluorescence atrophy area changes in treated eyes compared with sham group — 1 year","Autofluorescence atrophy area changes in treated eyes compared with sham group (1) — 1 year","ETDRS visual acuity — 1 year","Mean increase in ONL thickness and retinal volumetrics — 1 year","Mean increase in retinal volumetrics — 1 year","Stabilization of the atrophy region of the EPR — 1 year","Retinography of the ocular fundus — 1 year","Incomplete retinal pigment epithelial (RPE) and outer retinal atrophy (iRORA) — 1 year","Outer retinal atrophy (iRORA) — 1 year"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Dry Age-related Macular Degeneration","Intravitreal injection of CB-PRP"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct05706896","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-12-14 to 2026-02-10","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.856Z","intervention":["Intravitreal injection of CB-PRP"],"participants":36,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Autofluorescence atrophy area changes in treated eyes compared with sham group — 1 year","Autofluorescence atrophy area changes in treated eyes compared with sham group (1) — 1 year","ETDRS visual acuity — 1 year","Mean increase in ONL thickness and retinal volumetrics — 1 year","Mean increase in retinal volumetrics — 1 year","Stabilization of the atrophy region of the EPR — 1 year","Retinography of the ocular fundus — 1 year","Incomplete retinal pigment epithelial (RPE) and outer retinal atrophy (iRORA) — 1 year","Outer retinal atrophy (iRORA) — 1 year"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41705","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}