{"type":"trials","record":{"id":41755,"source_id":"clinicaltrials-gov","external_id":"NCT07060196","title":"The Impact of Artificial Lighting on the Visual Capacity of Patients With Age-Related Macular Degeneration","brief_summary":"Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in the elderly worldwide. The dry, non-exudative form of the disease, although more common, is associated with gradual and significant decline in functional vision. Despite advancements in diagnostic and therapeutic approaches, a targeted intervention that improves the daily functionality of these patients is still lacking. One critical, yet often overlooked, factor that affects daily performance is lighting conditions. This study aims to objectively assess the impact of different lighting intensity levels on patients with advanced dry AMD during the execution of everyday activities. A total of 60 individuals will be evaluated (30 healthy controls over 60 years of age and 30 patients with clinically diagnosed advanced AMD, according to NICE and AREDS criteria). Participants will undergo ophthalmological assessment (visual acuity, contrast sensitivity, OCT/OCTA, autofluorescence), and their performance on five functional tasks (mobility, object grasping, sit-to-stand transition, obstacle avoidance, and hanging clothes) will be evaluated under eight lighting levels (20-300 lux) at a constant color temperature (4000K), in a specially designed laboratory equipped with motion and eye-tracking systems. The primary endpoint is overall performance, based on task completion time and errors, expressed on a custom performance scale (0-100). Secondary data include changes in pupil size as an indicator of visual adaptation. The study aims to determine the optimal lighting range that maximizes functional vision and improves the quality of life for patients with AMD.","overall_status":"Not Yet Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Democritus University of Thrace","enrollment":70,"countries":["Greece"],"start_date":"2025-06-30","completion_date":"2027-01-31","last_update_date":"2025-07-11","source_url":"https://clinicaltrials.gov/study/NCT07060196","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Not Yet Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"ADLs AMD","age_range":"60 Years to 100 Years","comparator":null,"organization":"Democritus University of Thrace","interventions":["Distant Visual Acuity","Optical Coherence Tomography","Optical Coherence Tomography Angiography","Autofluorescence imaging"],"registry_source":"ClinicalTrials.gov","outcome_measures":["ADL score — On the same day as clinical evaluation, approximately 2-4 hours following baseline assessments.","Pupil Size — On the same day as clinical evaluation, approximately 2-4 hours following baseline assessments."],"design_description":null,"source_has_results":false},"controlled_terms":["AMD - Age-Related Macular Degeneration","Distant Visual Acuity","Optical Coherence Tomography","Optical Coherence Tomography Angiography","Autofluorescence imaging"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct07060196","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2025-06-30 to 2027-01-31","comparator":null,"confidence":"structured-source","population":"ALL · 60 Years to 100 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.866Z","intervention":["Distant Visual Acuity","Optical Coherence Tomography","Optical Coherence Tomography Angiography","Autofluorescence imaging"],"participants":70,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["ADL score — On the same day as clinical evaluation, approximately 2-4 hours following baseline assessments.","Pupil Size — On the same day as clinical evaluation, approximately 2-4 hours following baseline assessments."],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41755","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}