{"type":"trials","record":{"id":41770,"source_id":"clinicaltrials-gov","external_id":"NCT02686658","title":"Zimura in Participants With Geographic Atrophy Secondary to Dry Age-Related Macular Degeneration","brief_summary":"The objectives of this study were to evaluate the safety and efficacy of Zimura intravitreal (IVT) administration when administered in participants with geographic atrophy (GA) secondary to dry age-related macular degeneration (AMD).","overall_status":"Completed","phases":["PHASE2","PHASE3"],"study_type":"INTERVENTIONAL","sponsor":"IVERIC bio, Inc.","enrollment":286,"countries":["United States","Croatia","Czechia","Estonia","Hungary","Israel","Latvia"],"start_date":"2015-12-15","completion_date":"2020-04-23","last_update_date":"2025-06-10","source_url":"https://clinicaltrials.gov/study/NCT02686658","editorial_summary":"A registered PHASE2, PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years","comparator":null,"organization":"Astellas Pharma Inc","interventions":["Avacincaptad Pegol","Sham"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change From Baseline in Geographic Atrophy as Measured by Fundus Autofluorescence — Baseline and 12 months","Change From Baseline in Best Corrected Visual Acuity Using Early Treatment Diabetic Retinopathy Study Letters — Baselin…","Change From Baseline in Low Luminance BCVA Using Early Treatment Diabetic Retinopathy Study Letters — Baseline and 12 m…"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","source_has_results":true},"controlled_terms":["Geographic Atrophy","Dry Age-Related Macular Degeneration","Avacincaptad Pegol","Sham"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct02686658","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-12-15 to 2020-04-23","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.868Z","intervention":["Avacincaptad Pegol","Sham"],"participants":286,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2, PHASE3","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change From Baseline in Geographic Atrophy as Measured by Fundus Autofluorescence — Baseline and 12 months","Change From Baseline in Best Corrected Visual Acuity Using Early Treatment Diabetic Retinopathy Study Letters — Baselin…","Change From Baseline in Low Luminance BCVA Using Early Treatment Diabetic Retinopathy Study Letters — Baseline and 12 m…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41770","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}