{"type":"trials","record":{"id":41771,"source_id":"clinicaltrials-gov","external_id":"NCT04420923","title":"Optimizing the Treatment Strategy for Age-related Macular Degeneration","brief_summary":"The purpose of this study is to compare two different treatment protocols for wet macular degeneration; the new protocol called \"Observe and Plan\" against the current standard protocol \"Treat and Extend\". Studies suggest that patients achieve equally good visual acuity with fewer controls and that they are more satisfied with the new protocol.","overall_status":"Active Not Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"St. Olavs Hospital","enrollment":250,"countries":["Norway"],"start_date":"2020-05-20","completion_date":"2026-09-01","last_update_date":"2025-06-08","source_url":"https://clinicaltrials.gov/study/NCT04420923","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"OnP2","age_range":"50 Years","comparator":"Treat-and-Extend","organization":"St. Olavs Hospital","interventions":["Observe and Plan","Treat-and-Extend"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Visual acuity — 1 year","Visual acuity — 2 years","Patient satisfaction assessed by NEI-VFQ-25 — 1 year","Patient satisfaction assessed by NEI-VFQ-25 — 2 years","Number of injections — 1 year","Number of controls — 1 year","Number of injections — 2 years","Number of controls — 2 years"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Wet Macular Degeneration","Observe and Plan","Treat-and-Extend"],"relevance_confidence":80,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct04420923","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-05-20 to 2026-09-01","comparator":"Treat-and-Extend","confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.868Z","intervention":["Observe and Plan","Treat-and-Extend"],"participants":250,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Visual acuity — 1 year","Visual acuity — 2 years","Patient satisfaction assessed by NEI-VFQ-25 — 1 year","Patient satisfaction assessed by NEI-VFQ-25 — 2 years","Number of injections — 1 year","Number of controls — 1 year","Number of injections — 2 years","Number of controls — 2 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","title context","study type"],"relevance_score":80,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41771","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}