{"type":"trials","record":{"id":418,"source_id":"clinicaltrials-gov","external_id":"NCT04897113","title":"Study of Efficacy and Safety of the Plasmapheresis Method With Albumin Compensation Compared With the Plasmapheresis Method Without Albumin Compensation for Aging Biomarkers Correction in Men and Women Aged 40 to 55 Years Old","brief_summary":"Reaching active aging makes it important to implement new methods affecting the biological age of a person. Biochemical parameters of a blood test are aging biomarkers that are ones of the most accessible for testing. We know that, with age, there is increase in levels of LDL, triglycerides, homocysteine and other biomarkers relating the body state. Methods of extracorporeal hemocorrection showed good results in this area. For instance, the use of plasmapheresis is very effective during prophylaxis, treatment and rehabilitation after various diseases/injuries. The main effects of plasmapheresis are related to removal of endo- and exotoxins, including products of lipid peroxidation, and to draining effect as a result of a heavy flow of interstitial fluid containing products of pathometabolism into the blood stream within concentration gradient (by \"dynamic equilibrium\" in concentration o…","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"National Medical Research Center for Rehabilitation and Balneology","enrollment":80,"countries":["Russia"],"start_date":"2021-05-12","completion_date":"2022-12-30","last_update_date":"2021-05-21","source_url":"https://clinicaltrials.gov/study/NCT04897113","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-14T02:45:04.314999+00:00","last_seen_at":"2026-09-15T00:18:35.721+00:00","metadata":{"acronym":null,"organization":"National Medical Research Center for Rehabilitation and Balneology","source_has_results":false},"controlled_terms":[],"relevance_confidence":80,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Published automatically with 80% topic confidence after controlled-term evaluation.","quality_checked_at":"2026-09-15T02:15:56.576005+00:00","duplicate_cluster_key":"registry:nct04897113","duplicate_of_id":null,"clinical_trial_topics":[{"topic_slug":"plasma-exchange","is_published":true,"match_reasons":["Legacy trial evaluated automatically against controlled title, summary, and longevity-context rules."],"matched_fields":["title"],"relevance_score":80,"intelligence_topics":{"name":"Plasma exchange","slug":"plasma-exchange"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/418","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}