{"type":"trials","record":{"id":41814,"source_id":"clinicaltrials-gov","external_id":"NCT03585556","title":"AAVCAGsCD59 for the Treatment of Wet AMD","brief_summary":"Patients with treatment naive wet AMD will receive an intravitreal anti-VEGF injection at Day 0 followed by an intravitreal injection of AAVCAGsCD59 at Day 7. Patients will be followed monthly through Month 12 and receive an intravitreal anti-VEGF injection as needed based on an increase in central subfoveal thickness (CST) of \\>50 micrometers on OCT from Day 0, new subretinal hemorrhage on clinical exam, and/or loss of 10 or more ETDRS letters from the previous month exam.","overall_status":"Completed","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Janssen Research & Development, LLC","enrollment":25,"countries":["United States"],"start_date":"2018-09-13","completion_date":"2022-01-18","last_update_date":"2025-03-30","source_url":"https://clinicaltrials.gov/study/NCT03585556","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years","comparator":null,"organization":"Janssen Research & Development, LLC","interventions":["Intravitreal anti-VEGF","Intravitreal AAVCAGsCD59","Oral prednisolone"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Number of intravitreal anti-VEGF injections — 12 months","Number of patients with change in vision of ≥ 15 letters — 12 months","Number of patients with inflammation, endophthalmitis, IOP>30, retinal detachment, cataract, and systemic adverse event…"],"design_description":"NA · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Wet Age-related Macular Degeneration","Intravitreal anti-VEGF","Intravitreal AAVCAGsCD59","Oral prednisolone"],"relevance_confidence":60,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct03585556","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2018-09-13 to 2022-01-18","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.875Z","intervention":["Intravitreal anti-VEGF","Intravitreal AAVCAGsCD59","Oral prednisolone"],"participants":25,"study_design":"NA · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Number of intravitreal anti-VEGF injections — 12 months","Number of patients with change in vision of ≥ 15 letters — 12 months","Number of patients with inflammation, endophthalmitis, IOP>30, retinal detachment, cataract, and systemic adverse event…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Source terminology supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","controlled context","study type"],"relevance_score":60,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41814","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}