{"type":"trials","record":{"id":41827,"source_id":"clinicaltrials-gov","external_id":"NCT02800356","title":"Subthreshold Laser Treatment for Reticular Pseudodrusen and Geographic Atrophy Secondary to AMD","brief_summary":"To evaluate the effectiveness of subthreshold laser treatment on retinal sensitivity in patients with reticular pseudodrusen and incipient Geographic Atrophy (GA) secondary to Age-Related Macular Degeneration (AMD). Secondary objective is to investigate changes in best-corrected visual acuity, atrophy progression and safety.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Ospedale San Raffaele","enrollment":20,"countries":["Italy"],"start_date":"2016-06-01","completion_date":"2019-09-01","last_update_date":"2025-03-20","source_url":"https://clinicaltrials.gov/study/NCT02800356","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years","comparator":null,"organization":"Ospedale San Raffaele","interventions":["Subthreshold 577 nm yellow wavelength laser photo-coagulator"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Retinal Sensitivity — Baseline, 4 weeks and 12 weeks","Visual Acuity — Baseline, 4 weeks and 12 weeks","The Thickness of the Outer Nuclear Layer in the Treated Area — Baseline, 4 weeks and 12 weeks","Number of Partecipants With Adverse and Serious Adverse Events — 4 weeks and 12 weeks","Number of Partecipants With Presence of Haemorrhage, Photocoagulation Spots, Ischemic Areas — 4 weeks and 12 weeks","Intraocular Pressure — 4 weeks and 12 weeks"],"design_description":"NON RANDOMIZED · PARALLEL · TREATMENT · NONE","source_has_results":true},"controlled_terms":["Age-Related Macular Degeneration","Geographic Atrophy","Reticular Pseudodrusen","Subthreshold 577 nm yellow wavelength laser photo-coagulator"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct02800356","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-06-01 to 2019-09-01","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.877Z","intervention":["Subthreshold 577 nm yellow wavelength laser photo-coagulator"],"participants":20,"study_design":"NON RANDOMIZED · PARALLEL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Retinal Sensitivity — Baseline, 4 weeks and 12 weeks","Visual Acuity — Baseline, 4 weeks and 12 weeks","The Thickness of the Outer Nuclear Layer in the Treated Area — Baseline, 4 weeks and 12 weeks","Number of Partecipants With Adverse and Serious Adverse Events — 4 weeks and 12 weeks","Number of Partecipants With Presence of Haemorrhage, Photocoagulation Spots, Ischemic Areas — 4 weeks and 12 weeks","Intraocular Pressure — 4 weeks and 12 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41827","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}