{"type":"trials","record":{"id":41848,"source_id":"clinicaltrials-gov","external_id":"NCT05832996","title":"Cool vs Room-temperature Artificial Tears","brief_summary":"Background and Objective: To evaluate the efficacy of cooled versus room temperature artificial tears in reducing post intravitreal injection (IVI) ocular discomfort. Patients and Methods: Patients receiving IVI were randomized to either cooled or room temperature tears intervention groups. Both groups rated their ocular discomfort following IVI before intervention and again after administration of cooled or room temperature tears.","overall_status":"Completed","phases":["PHASE4"],"study_type":"INTERVENTIONAL","sponsor":"University of Iowa","enrollment":124,"countries":["United States"],"start_date":"2022-03-01","completion_date":"2022-07-06","last_update_date":"2025-03-04","source_url":"https://clinicaltrials.gov/study/NCT05832996","editorial_summary":"A registered PHASE4 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years to 105 Years","comparator":"Room temperature artificial tear group","organization":"University of Iowa","interventions":["Refresh Plus Preservative-free Lubricant Eye Drops"],"registry_source":"ClinicalTrials.gov","outcome_measures":["The Efficacy of Cooled Versus Room Temperature Artificial Tears in Reducing Post Intravitreal Injection Ocular Discomfo…"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","source_has_results":true},"controlled_terms":["Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis)","Central Retinal Vein Occlusion With Macular Edema","Exudative Age-Related Macular Degeneration, Unspecified Eye","Cystoid Macular Edema","Ocular Surface Disease","Dry Eye Sensation","Eye Pain","Refresh Plus Preservative-free Lubricant Eye Drops"],"relevance_confidence":60,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct05832996","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-03-01 to 2022-07-06","comparator":"Room temperature artificial tear group","confidence":"structured-source","population":"ALL · 18 Years to 105 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.880Z","intervention":["Refresh Plus Preservative-free Lubricant Eye Drops"],"participants":124,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE4","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["The Efficacy of Cooled Versus Room Temperature Artificial Tears in Reducing Post Intravitreal Injection Ocular Discomfo…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Source terminology supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","controlled context","study type"],"relevance_score":60,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41848","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}