{"type":"trials","record":{"id":41884,"source_id":"clinicaltrials-gov","external_id":"NCT02225119","title":"The Focal Electro-Oculogram in Macular Disease","brief_summary":"Background: \\- Maculopathies are eye conditions that affect the center of the retina. Retina health depends on the retinal pigment epithelium (RPE), a layer behind the retina. A new test may measure the health of the central retina and RPE. Objective: \\- To use the focal electro-oculogram (EOG) test to understand how the central retina and RPE are affected in maculopathies. Eligibility: * People at least 10 years old with a maculopathy. * Healthy volunteers with visual acuity of 20/20 or better in at least one eye. Design: * Participants will be screened with medical and eye history and an eye exam. Pictures will be taken of the eyes. * Their eyes may be dilated. * They may have a field test. They will look into a lens and press a button when they see a light. First, they may sit in the dark for 40 minutes. * Participants will have 1-7 visits over 18 months. * Their vision will be tested and eye pressure measured. * Their pupils will be dilated with eye drops and researchers may take pictures of the retina and the inside of the eye, and measure the thickness of the retina. * Participants will have an electro-oculogram. They will look at a 2 LED lights and follow them back and forth for 10 seconds once per minute. Participants will be in darkness for 15 minutes and in light for 20 minutes. One skin electrode will be placed on the nose and one next to the eye. * Participants with maculopathy will also have: * Field test. * Electroretinogram. Participants will get numbing eye drops and special contact lenses. A small metal electrode will be taped to the forehead. Participants will watch flashing lights and try not to blink. First, they may sit in the dark for 40 minutes.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"National Eye Institute (NEI)","enrollment":39,"countries":["United States"],"start_date":"2015-02-06","completion_date":"2020-02-28","last_update_date":"2024-12-11","source_url":"https://clinicaltrials.gov/study/NCT02225119","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"10 Years to 100 Years","comparator":null,"organization":"National Institutes of Health Clinical Center (CC)","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["develop method for recording focal EOG — up to 6 months","establish the normal range for the focal EOG and determine the inter-session and intra-session variabilities of this te…"],"design_description":null,"source_has_results":false},"controlled_terms":["Macular Degeneration","Age-Related Macular Degeneration"],"relevance_confidence":60,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct02225119","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-02-06 to 2020-02-28","comparator":null,"confidence":"structured-source","population":"ALL · 10 Years to 100 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.886Z","intervention":[],"participants":39,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["develop method for recording focal EOG — up to 6 months","establish the normal range for the focal EOG and determine the inter-session and intra-session variabilities of this te…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Source terminology supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["controlled terminology","controlled context","study type"],"relevance_score":60,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41884","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}