{"type":"trials","record":{"id":41888,"source_id":"clinicaltrials-gov","external_id":"NCT05438732","title":"Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMD","brief_summary":"The objective of this study is to determine the safety and effectiveness of the smaller incision, new generation (SING), implantable miniature telescope (IMT) in patients with moderate-severe central vision loss due to late-stage age-related macular degeneration (AMD).","overall_status":"Recruiting","phases":[],"study_type":"INTERVENTIONAL","sponsor":"VisionCare, Inc.","enrollment":125,"countries":["United States"],"start_date":"2022-06-16","completion_date":"2025-12-01","last_update_date":"2024-12-03","source_url":"https://clinicaltrials.gov/study/NCT05438732","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"CONCERTO","age_range":"65 Years","comparator":null,"organization":"VisionCare, Inc.","interventions":["smaller incision, new generation implantable miniature telescope (SING-IMT)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Primary Effectiveness Outcome — Approximately 12-months post-operatively (330-420 days)","Primary Safety Outcome — Approximately 12-months post-operatively (330-420 days)","Best-corrected distance visual acuity (BCDVA) — Approximately 12-months post-operatively (330-420 days)","Best-corrected near visual acuity (BCNVA) — Approximately 12-months post-operatively (330-420 days)","Anterior Chamber Depth — Approximately 12-months post-operatively (330-420 days)","IMT position — Approximately 12-months post-operatively (330-420 days)","Adverse Events — Approximately 12-months post-operatively (330-420 days)","Posterior Capsule Opacification — Approximately 12-months post-operatively (330-420 days)"],"design_description":"NA · SINGLE GROUP · OTHER · NONE","source_has_results":false},"controlled_terms":["Age-Related Macular Degeneration","Geographic Atrophy","smaller incision, new generation implantable miniature telescope (SING-IMT)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct05438732","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-06-16 to 2025-12-01","comparator":null,"confidence":"structured-source","population":"ALL · 65 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.887Z","intervention":["smaller incision, new generation implantable miniature telescope (SING-IMT)"],"participants":125,"study_design":"NA · SINGLE GROUP · OTHER · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Primary Effectiveness Outcome — Approximately 12-months post-operatively (330-420 days)","Primary Safety Outcome — Approximately 12-months post-operatively (330-420 days)","Best-corrected distance visual acuity (BCDVA) — Approximately 12-months post-operatively (330-420 days)","Best-corrected near visual acuity (BCNVA) — Approximately 12-months post-operatively (330-420 days)","Anterior Chamber Depth — Approximately 12-months post-operatively (330-420 days)","IMT position — Approximately 12-months post-operatively (330-420 days)","Adverse Events — Approximately 12-months post-operatively (330-420 days)","Posterior Capsule Opacification — Approximately 12-months post-operatively (330-420 days)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41888","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}