{"type":"trials","record":{"id":41906,"source_id":"clinicaltrials-gov","external_id":"NCT04269304","title":"Deciphering AMD by Deep Phenotyping and Machine Learning- Prospective Study - PINNACLE","brief_summary":"We will conduct a prospective non-interventional study including 400 early AMD patients (=600 untreated early AMD eyes, including both unilateral (AREDS IV) and bilateral (≥AREDS II)) over a minimum of 1 year to specifically investigate the morphological sequence of events preceding the conversion towards late AMD. All patients will be followed by Optical Coherence Tomography (OCT) imaging every 4 months to detect the earliest focal sites of disease progression. As soon as focal areas of change are observed by the Vienna Reading Center (VRC), a targeted follow-up schedule will be triggered to investigate the events at that area of change in a targeted manner.","overall_status":"Active Not Recruiting","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University of Southampton","enrollment":429,"countries":["Austria","Switzerland","United Kingdom"],"start_date":"2019-10-28","completion_date":"2025-06-01","last_update_date":"2024-11-12","source_url":"https://clinicaltrials.gov/study/NCT04269304","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Active Not Recruiting. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"PINNACLE","age_range":"55 Years to 90 Years","comparator":null,"organization":"University of Southampton","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["Sensitivity / specificity of OCT and autofluorescence parameters. — 3 years","Sensitivity / specificity of novel imaging characteristics — 3 years"],"design_description":null,"source_has_results":false},"controlled_terms":["Age-related Macular Degeneration"],"relevance_confidence":62,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct04269304","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-10-28 to 2025-06-01","comparator":null,"confidence":"structured-source","population":"ALL · 55 Years to 90 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.890Z","intervention":[],"participants":429,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Sensitivity / specificity of OCT and autofluorescence parameters. — 3 years","Sensitivity / specificity of novel imaging characteristics — 3 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["controlled terminology","abstract context","study type"],"relevance_score":62,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41906","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}