{"type":"trials","record":{"id":41960,"source_id":"clinicaltrials-gov","external_id":"NCT05562219","title":"QA108 Phase II Study in Subjects With Intermediate Age-Related Macular Degeneration","brief_summary":"This is a phase 2, randomized, double-masked, placebo-controlled, multicenter study. To evaluate the efficacy and safety of QA108 granules in the treatment of intermediate age-related macular degeneration.","overall_status":"Completed","phases":["PHASE2"],"study_type":"INTERVENTIONAL","sponsor":"Smilebiotek Zhuhai Limited","enrollment":120,"countries":["China"],"start_date":"2022-06-29","completion_date":"2024-06-24","last_update_date":"2024-07-15","source_url":"https://clinicaltrials.gov/study/NCT05562219","editorial_summary":"A registered PHASE2 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"45 Years to 85 Years","comparator":"Placebo group(QA108 granule simulants)","organization":"Smilebiotek Zhuhai Limited","interventions":["QA108 granules","QA108 granules placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Percentage change from baseline in drusen area . — weeks 24","Percentage change from baseline in drusen area — weeks 4,8,12,16,20"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","source_has_results":false},"controlled_terms":["Intermediate Age-Related Macular Degeneration","QA108 granules","QA108 granules placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct05562219","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-06-29 to 2024-06-24","comparator":"Placebo group(QA108 granule simulants)","confidence":"structured-source","population":"ALL · 45 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.900Z","intervention":["QA108 granules","QA108 granules placebo"],"participants":120,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Percentage change from baseline in drusen area . — weeks 24","Percentage change from baseline in drusen area — weeks 4,8,12,16,20"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/41960","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}