{"type":"trials","record":{"id":42073,"source_id":"clinicaltrials-gov","external_id":"NCT05064865","title":"Impact of Regular Consumption of Grapes on Eye Health in Singapore Older Adults","brief_summary":"Aging epidemics in Singapore are rapidly increasing and Age-related macular degeneration (AMD) prevalence is significantly associated with older age. This study aims to understand the effect of consuming freeze-dried table grape powder on AMD in an older population.","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"National University of Singapore","enrollment":34,"countries":["Singapore"],"start_date":"2022-01-28","completion_date":"2024-10-01","last_update_date":"2023-11-09","source_url":"https://clinicaltrials.gov/study/NCT05064865","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"60 Years to 85 Years","comparator":"Placebo grape powder","organization":"National University of Singapore","interventions":["Freeze-dried table grape powder","Placebo of the table grape powder"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change in macular pigment optical density — Every four weeks (week 0, week 4, week 8, week 12, week 16)","Change in skin carotenoid status — Every four weeks (week 0, week 4, week 8, week 12, week 16)","Change in blood carotenoid concentration — Every eight weeks (week 0, week 8, week 16)","Change in flow mediate dilation — week 0 and week 16","Change in endothelial function — week 0 and week 16","Change in the concentration if Endothelin-1 in plasma — week 0 and week 16","Change in the concentration if Nitric Oxide in plasma — week 0 and week 16","Change in body weight — Every four weeks (week 0, week 4, week 8, week 12, week 16)","Change in BMI — Every four weeks (week 0, week 4, week 8, week 12, week 16)","Change in blood pressure — Every four weeks (week 0, week 4, week 8, week 12, week 16)","change in waist circumference — Every four weeks (week 0, week 4, week 8, week 12, week 16)","Change in the concentration of malondialdehyde in plasma — Every eight weeks (week 0, week 8, week 16)","Change in the concentration of 8-iso-prostaglandin F2α in plasma — Every eight weeks (week 0, week 8, week 16)","Change in blood glucose concentration — Every eight weeks (week 0, week 8, week 16)","Change in total cholesterol — Every eight weeks (week 0, week 8, week 16)","Change in high-density lipoprotein cholesterol — Every eight weeks (week 0, week 8, week 16)","Change in low-density lipoprotein cholesterol — Every eight weeks (week 0, week 8, week 16)","Change in total triglyceride — Every eight weeks (week 0, week 8, week 16)"],"design_description":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","source_has_results":false},"controlled_terms":["Eye Health","Age-related Macular Degeneration","Freeze-dried table grape powder","Placebo of the table grape powder"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":65,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct05064865","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-01-28 to 2024-10-01","comparator":"Placebo grape powder","confidence":"structured-source","population":"ALL · 60 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.916Z","intervention":["Freeze-dried table grape powder","Placebo of the table grape powder"],"participants":34,"study_design":"RANDOMIZED · PARALLEL · PREVENTION · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change in macular pigment optical density — Every four weeks (week 0, week 4, week 8, week 12, week 16)","Change in skin carotenoid status — Every four weeks (week 0, week 4, week 8, week 12, week 16)","Change in blood carotenoid concentration — Every eight weeks (week 0, week 8, week 16)","Change in flow mediate dilation — week 0 and week 16","Change in endothelial function — week 0 and week 16","Change in the concentration if Endothelin-1 in plasma — week 0 and week 16","Change in the concentration if Nitric Oxide in plasma — week 0 and week 16","Change in body weight — Every four weeks (week 0, week 4, week 8, week 12, week 16)","Change in BMI — Every four weeks (week 0, week 4, week 8, week 12, week 16)","Change in blood pressure — Every four weeks (week 0, week 4, week 8, week 12, week 16)","change in waist circumference — Every four weeks (week 0, week 4, week 8, week 12, week 16)","Change in the concentration of malondialdehyde in plasma — Every eight weeks (week 0, week 8, week 16)","Change in the concentration of 8-iso-prostaglandin F2α in plasma — Every eight weeks (week 0, week 8, week 16)","Change in blood glucose concentration — Every eight weeks (week 0, week 8, week 16)","Change in total cholesterol — Every eight weeks (week 0, week 8, week 16)","Change in high-density lipoprotein cholesterol — Every eight weeks (week 0, week 8, week 16)","Change in low-density lipoprotein cholesterol — Every eight weeks (week 0, week 8, week 16)","Change in total triglyceride — Every eight weeks (week 0, week 8, week 16)"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: older adult.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42073","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}