{"type":"trials","record":{"id":42111,"source_id":"clinicaltrials-gov","external_id":"NCT01782352","title":"Age-related Macular Degeneration (AMD) in the Vitamin D and Omega-3 Trial (VITAL)","brief_summary":"The VITamin D and OmegA-3 Trial (VITAL; NCT 01169259) is a randomized clinical trial in 25,875 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids (Omacor fish oil, 1 gram) reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses. This ancillary study is being conducted among participants in VITAL and will examine whether vitamin D or omega-3 fatty acids, compared to placebo, reduce the incidence and/or progression of age-related macular degeneration (AMD).","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Brigham and Women's Hospital","enrollment":25871,"countries":["United States"],"start_date":"2010-07-01","completion_date":"2024-09-01","last_update_date":"2023-08-08","source_url":"https://clinicaltrials.gov/study/NCT01782352","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years","comparator":"Vitamin D + fish oil placebo; Vitamin D placebo + fish oil; Vitamin D placebo + fish oil placebo; Vitamin D + fish oil","organization":"Brigham and Women's Hospital","interventions":["Omega-3 fatty acids (fish oil)","Vitamin D3","Vitamin D3 placebo","Fish oil placebo"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Number of Participants With an AMD Event — 5 years","Number of Participants With Incident Visually-Significant AMD — 5 years","Number of Participants With Incident Advanced AMD — 5 years"],"design_description":"RANDOMIZED · FACTORIAL · PREVENTION · TRIPLE","source_has_results":true},"controlled_terms":["Age-related Macular Degeneration","Omega-3 fatty acids (fish oil)","Vitamin D3","Vitamin D3 placebo","Fish oil placebo"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct01782352","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2010-07-01 to 2024-09-01","comparator":"Vitamin D + fish oil placebo; Vitamin D placebo + fish oil; Vitamin D placebo + fish oil placebo; Vitamin D + fish oil","confidence":"structured-source","population":"ALL · 50 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.921Z","intervention":["Omega-3 fatty acids (fish oil)","Vitamin D3","Vitamin D3 placebo","Fish oil placebo"],"participants":25871,"study_design":"RANDOMIZED · FACTORIAL · PREVENTION · TRIPLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Number of Participants With an AMD Event — 5 years","Number of Participants With Incident Visually-Significant AMD — 5 years","Number of Participants With Incident Advanced AMD — 5 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42111","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}