{"type":"trials","record":{"id":42136,"source_id":"clinicaltrials-gov","external_id":"NCT03614481","title":"Clinical and Genetic Analyzes of Age-related Macular Degeneration","brief_summary":"The purpose of this collection is to search for susceptibility genes for age-related macular degeneration (AMD) alone or in combination with environmental factors and to look for genes that modulate the AMD phenotype (particularly the response to treatment).","overall_status":"Unknown","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Centre Hospitalier Intercommunal Creteil","enrollment":6000,"countries":["France"],"start_date":"2005-11-01","completion_date":"2024-11-01","last_update_date":"2023-05-15","source_url":"https://clinicaltrials.gov/study/NCT03614481","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"COLDMLA","age_range":"55 Years","comparator":null,"organization":"Centre Hospitalier Intercommunal Creteil","interventions":["Sampling"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Genotypic factors — 6 months","Predictive markers — 6 months","Vascular Endothelial Growth Factor — 6 months","Environmental factors — 6 months","Predictive treatment response score — 6 months","Circulating biological factors — 6 months"],"design_description":null,"source_has_results":false},"controlled_terms":["Macular Degeneration","Sampling"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct03614481","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2005-11-01 to 2024-11-01","comparator":null,"confidence":"structured-source","population":"ALL · 55 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.925Z","intervention":["Sampling"],"participants":6000,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Genotypic factors — 6 months","Predictive markers — 6 months","Vascular Endothelial Growth Factor — 6 months","Environmental factors — 6 months","Predictive treatment response score — 6 months","Circulating biological factors — 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42136","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}