{"type":"trials","record":{"id":42153,"source_id":"clinicaltrials-gov","external_id":"NCT02951351","title":"Topical Proparacaine Eye Drops to Improve the Experience of Patients Undergoing Intravitreal Injections","brief_summary":"The specific aims of this study are to compare patient experience with and without a proparacaine drop after povidone iodine.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Mayo Clinic","enrollment":36,"countries":["United States"],"start_date":"2016-10-12","completion_date":"2018-02-01","last_update_date":"2023-04-12","source_url":"https://clinicaltrials.gov/study/NCT02951351","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":"Standard procedure + Culture","organization":"Mayo Clinic","interventions":["Proparacaine","Conjunctival culture"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Number of Study Participants With Positive Conjunctival Culture — pre-injection","Pain at the Time of Injection — post-injection","Residual Pain From Intravitreal Injection — post-injection","Overall Impression of Visit for Intravitreal Injection — post-injection","Impression of Pre-injection Preparations — post-injection","Comfort With Intravitreal Injection Standard Procedure — post-injection","Expectation Intravitreal Injection Will Have Negative Consequences on Subject Health — post-injection","Expectation the Injection Will Contribute to Curing/Improving Eye Condition — post-injection"],"design_description":"RANDOMIZED · PARALLEL · OTHER · SINGLE","source_has_results":true},"controlled_terms":["Age-related Macular Degeneration","Diabetic Macular Edema","Injection Site","Injection Site Infection","Pain, Postoperative","Proparacaine","Conjunctival culture"],"relevance_confidence":60,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct02951351","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-10-12 to 2018-02-01","comparator":"Standard procedure + Culture","confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.927Z","intervention":["Proparacaine","Conjunctival culture"],"participants":36,"study_design":"RANDOMIZED · PARALLEL · OTHER · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Number of Study Participants With Positive Conjunctival Culture — pre-injection","Pain at the Time of Injection — post-injection","Residual Pain From Intravitreal Injection — post-injection","Overall Impression of Visit for Intravitreal Injection — post-injection","Impression of Pre-injection Preparations — post-injection","Comfort With Intravitreal Injection Standard Procedure — post-injection","Expectation Intravitreal Injection Will Have Negative Consequences on Subject Health — post-injection","Expectation the Injection Will Contribute to Curing/Improving Eye Condition — post-injection"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Source terminology supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","controlled context","study type"],"relevance_score":60,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42153","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}