{"type":"trials","record":{"id":42182,"source_id":"clinicaltrials-gov","external_id":"NCT03835884","title":"A Study Assessing AR-13503 Implant in Subjects With nAMD or DME","brief_summary":"First-in-Human Study of the Safety of AR-13503 Sustained Release Intravitreal Implant in Subjects with Neovascular Age-Related Macular Degeneration (nAMD) and Subjects with Diabetic Macular Edema (DME)","overall_status":"Completed","phases":["PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"Aerie Pharmaceuticals","enrollment":18,"countries":["United States"],"start_date":"2019-06-24","completion_date":"2022-05-12","last_update_date":"2023-02-09","source_url":"https://clinicaltrials.gov/study/NCT03835884","editorial_summary":"A registered PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":null,"organization":"Aerie Pharmaceuticals","interventions":["AR-13503 Implant 10.6 Dose","AR-13503 Implant 21.2 Dose","AR-13503 42.4 Dose","AR-13503 63.6 Dose"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Number of ocular and non-ocular TEAEs — 24 weeks"],"design_description":"RANDOMIZED · SEQUENTIAL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Neovascular Age-related Macular Degeneration","Diabetic Macular Edema","AR-13503 Implant 10.6 Dose","AR-13503 Implant 21.2 Dose","AR-13503 42.4 Dose","AR-13503 63.6 Dose"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct03835884","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-06-24 to 2022-05-12","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.931Z","intervention":["AR-13503 Implant 10.6 Dose","AR-13503 Implant 21.2 Dose","AR-13503 42.4 Dose","AR-13503 63.6 Dose"],"participants":18,"study_design":"RANDOMIZED · SEQUENTIAL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Number of ocular and non-ocular TEAEs — 24 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42182","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}