{"type":"trials","record":{"id":42189,"source_id":"clinicaltrials-gov","external_id":"NCT03958461","title":"Connection Between Periodontitis and Exudative Age-related Macular Degeneration","brief_summary":"Aqueous flare is increased in different kind of inflammations of eye. This is caused by disruption of blood-aqueous-barrier. The investigators assume that low grade systemic inflammation, such as periodontitis, increase aqueous flare and possibly activates exudative age-related macular degeneration.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"University of Helsinki","enrollment":13,"countries":["Finland"],"start_date":"2020-01-01","completion_date":"2022-12-07","last_update_date":"2023-01-30","source_url":"https://clinicaltrials.gov/study/NCT03958461","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"FLAREPARO","age_range":"18 Years to 100 Years","comparator":null,"organization":"University of Helsinki","interventions":["Anti-infective treatment of periodontal pockets"],"registry_source":"ClinicalTrials.gov","outcome_measures":["<10pu/msec to over 300pu/msec — Change from Baseline aqueous flare value at 6 weeks"],"design_description":"NA · SINGLE GROUP · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Periodontitis","Anti-infective treatment of periodontal pockets"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct03958461","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-01-01 to 2022-12-07","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years to 100 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.933Z","intervention":["Anti-infective treatment of periodontal pockets"],"participants":13,"study_design":"NA · SINGLE GROUP · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["<10pu/msec to over 300pu/msec — Change from Baseline aqueous flare value at 6 weeks"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42189","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}