{"type":"trials","record":{"id":42191,"source_id":"clinicaltrials-gov","external_id":"NCT02521142","title":"Non-invasive Optical Angiography in Age-related Macular Degeneration","brief_summary":"Age-related macular degeneration (AMD) is the leading cause of severe and irreversible visual loss and classified blindness in the elderly throughout Europe and the US. Among these patients, about 6%-8% are afflicted with the advanced stages of AMD, which are responsible for the most severe visual loss. There is now convincing evidence that vascular endothelial growth factor (VEGF) is a major trigger for the formation of pathological choroidal vessels, responsible for the development of the neovascular form of AMD. Today, the gold standard for vascular imaging of the retina and diagnosis of CNV is angiography using fluorescein (FLA) or indocyanine green (ICG), which involves injection of the dye into a vein of the arm. In the recent years tremendous enhancements in the field of optical coherence tomography have been achieved. These developments made it possible to visualize the retinal vasculature in a full depth manner without the application of an intravenous marker. The proposed study tests the hypothesis that visualisation of CNV lesion size with non-invasive OCT angiography is not inferior to FLA/ICG angiography in treatment naïve and previously treated AMD patients.","overall_status":"Unknown","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Medical University of Vienna","enrollment":72,"countries":["Austria"],"start_date":"2015-11-01","completion_date":"2023-12-01","last_update_date":"2023-01-17","source_url":"https://clinicaltrials.gov/study/NCT02521142","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":null,"comparator":null,"organization":"Medical University of Vienna","interventions":["Non-invasive OCT based optical angiography","Oxymap T1","OCT","FLA/ICG angiography"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Differences in visualization of lesion size between non-invasive OCT based optical angiography and FLA/ICG angiography…","choroidal thickness as assessed with OCT — participants will be followed for the duration of outpatient clinic visit, a…","peripapillarly bloodflow as assessed with Doppler OCT — participants will be followed for the duration of outpatient cl…"],"design_description":null,"source_has_results":false},"controlled_terms":["Age Related Macular Degeneration","Non-invasive OCT based optical angiography","Oxymap T1","OCT","FLA/ICG angiography"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct02521142","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-11-01 to 2023-12-01","comparator":null,"confidence":"structured-source","population":"ALL","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.933Z","intervention":["Non-invasive OCT based optical angiography","Oxymap T1","OCT","FLA/ICG angiography"],"participants":72,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Differences in visualization of lesion size between non-invasive OCT based optical angiography and FLA/ICG angiography…","choroidal thickness as assessed with OCT — participants will be followed for the duration of outpatient clinic visit, a…","peripapillarly bloodflow as assessed with Doppler OCT — participants will be followed for the duration of outpatient cl…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42191","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}