{"type":"trials","record":{"id":42194,"source_id":"clinicaltrials-gov","external_id":"NCT04636853","title":"CB-PRP in Retinitis Pigmentosa and Dry Age-related Macular Degeneration","brief_summary":"The study will provides the enrollment of patients with genetic retinal dystrophies with primary rod impairment and dry age-related macular degeneration (Geographic type) A subretinal injection of umbilical cord blood platelet-rich plasma (CB-PRP) will be performed only in one eye, the other eye will be considered as a control group. A complete morpho-functional ophthalmological evaluation will be performed in all patients at each control.","overall_status":"Completed","phases":["PHASE3"],"study_type":"INTERVENTIONAL","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","enrollment":20,"countries":["Italy"],"start_date":"2020-12-23","completion_date":"2021-12-02","last_update_date":"2023-01-11","source_url":"https://clinicaltrials.gov/study/NCT04636853","editorial_summary":"A registered PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":"SiCord","age_range":"18 Years to 70 Years","comparator":null,"organization":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","interventions":["Subretinal injection of umbilical cord blood platelet-rich plasma (CB-PRP)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) morphological changes — 3 years"],"design_description":"NA · SEQUENTIAL · TREATMENT · NONE","source_has_results":false},"controlled_terms":["Retinitis Pigmentosa","Dry Age-related Macular Degeneration","Subretinal injection of umbilical cord blood platelet-rich plasma (CB-PRP)"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct04636853","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-12-23 to 2021-12-02","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years to 70 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.933Z","intervention":["Subretinal injection of umbilical cord blood platelet-rich plasma (CB-PRP)"],"participants":20,"study_design":"NA · SEQUENTIAL · TREATMENT · NONE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE3","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) morphological changes — 3 years"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Title contains controlled term: age-related macular degeneration.","Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Title supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","controlled terminology","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42194","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}