{"type":"trials","record":{"id":42277,"source_id":"clinicaltrials-gov","external_id":"NCT02102880","title":"The Role of Complement Factor H Polymorphism in the Regulation of Choroidal Vascular Tone in Young Healthy Subjects","brief_summary":"Age related macular degeneration (AMD) is a multifactorial disease with a strong genetic component. Given that it is known that impaired regulation of choroidal vascular tone is present in patients with AMD, the current study seeks to investigate whether genetic polymorphisms in risk alleles for AMD are associated with altered choroidal blood flow regulation in healthy subjects. For this purpose a total of 220 healthy volunteers will be included. Choroidal blood flow regulation will be evaluated by measuring choroidal blood flow during isometric exercise. In addition, flicker induced vasodilatation will be studied and retinal vessel calibers will assessed, as well as retinal thickness and macular pigment optical density.","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Medical University of Vienna","enrollment":220,"countries":["Austria"],"start_date":"2015-03-01","completion_date":"2023-09-02","last_update_date":"2022-04-07","source_url":"https://clinicaltrials.gov/study/NCT02102880","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years to 45 Years","comparator":null,"organization":"Medical University of Vienna","interventions":["the polymerase chain reaction (PCR)"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Choroidal blood flow during isometric exercise (LDF) — 1 day","Flicker induced vasodilatation, expressed as percent change to baseline (DVA) — 1 day","Genotyping (PCR) — 1 day","Retinal vessel calibers and AV- ratio (DVA) — 1 day","Laser Speckle Flowmetry (LSFG) — 1 day"],"design_description":"NA · SINGLE GROUP · OTHER · NONE","source_has_results":false},"controlled_terms":["Age-Related Macular Degeneration","the polymerase chain reaction (PCR)"],"relevance_confidence":60,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Source terminology contains: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct02102880","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2015-03-01 to 2023-09-02","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years to 45 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.945Z","intervention":["the polymerase chain reaction (PCR)"],"participants":220,"study_design":"NA · SINGLE GROUP · OTHER · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Choroidal blood flow during isometric exercise (LDF) — 1 day","Flicker induced vasodilatation, expressed as percent change to baseline (DVA) — 1 day","Genotyping (PCR) — 1 day","Retinal vessel calibers and AV- ratio (DVA) — 1 day","Laser Speckle Flowmetry (LSFG) — 1 day"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Source terminology contains: age-related macular degeneration.","Source terminology supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["controlled terminology","controlled context","study type"],"relevance_score":60,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42277","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}