{"type":"trials","record":{"id":42280,"source_id":"clinicaltrials-gov","external_id":"NCT05297292","title":"A Study to Evaluate the Efficacy and Safety of MW02 in the Treatment of nAMD","brief_summary":"The purpose of this study is to compare the efficacy and safety of MW02 versus Lucentis in the treatment of neovascular age-related macular degeneration.The study was divided into two stages. The first stage was to explore the dose and the second stage was to explore the frequency of administration.","overall_status":"Unknown","phases":["PHASE2","PHASE3"],"study_type":"INTERVENTIONAL","sponsor":"Mabwell (Shanghai) Bioscience Co., Ltd.","enrollment":433,"countries":["China"],"start_date":"2021-05-07","completion_date":"2024-06-30","last_update_date":"2022-03-28","source_url":"https://clinicaltrials.gov/study/NCT05297292","editorial_summary":"A registered PHASE2, PHASE3 study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years to 80 Years","comparator":"Lucentis-0.5mg（Q4w）","organization":"Mabwell (Shanghai) Bioscience Co., Ltd.","interventions":["MW02","Lucentis"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change from Baseline in Best Corrected Visual Acuity (BCVA) — At week 52","Change from Baseline in BCVA — baseline to week 52"],"design_description":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","source_has_results":false},"controlled_terms":["Wet Age-related Macular Degeneration","MW02","Lucentis"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct05297292","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2021-05-07 to 2024-06-30","comparator":"Lucentis-0.5mg（Q4w）","confidence":"structured-source","population":"ALL · 50 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.945Z","intervention":["MW02","Lucentis"],"participants":433,"study_design":"RANDOMIZED · PARALLEL · TREATMENT · QUADRUPLE","subject_scope":"Human clinical study registration","evidence_stage":"PHASE2, PHASE3","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change from Baseline in Best Corrected Visual Acuity (BCVA) — At week 52","Change from Baseline in BCVA — baseline to week 52"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: age-related.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42280","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}