{"type":"trials","record":{"id":42311,"source_id":"clinicaltrials-gov","external_id":"NCT04723160","title":"Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph","brief_summary":"Blindness can be caused by many ocular diseases, such as diabetic retinopathy, retinal vein occlusion, age-related macular degeneration, pathologic myopia and glaucoma. Without timely diagnosis and adequate medical intervention, the visual impairment can become a great burden on individuals as well as the society. It is estimated that China has 110 million patients under the attack of diabetes, 180 million patients with hypertension, 120 million patients suffering from high myopia and 200 million people over 60 years old, which suggest a huge population at the risk of blindness. Despite of this crisis in public health, our society has no more than 3,000 ophthalmologists majoring in fundus oculi disease currently. As most of them assembling in metropolitan cities, health system in this field is frail in primary hospitals. Owing to this unreasonable distribution of medical resources, providing medical service to hundreds of millions of potential patients threatened with blindness is almost impossible. To solve this problem, this software (MCS) was developed as a computer-aided diagnosis to help junior ophthalmologists to detect 13 major retina diseases from color fundus photographs. This study has been designed to validate the safety and efficiency of this device.","overall_status":"Completed","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Visionary Intelligence Ltd.","enrollment":748,"countries":["China"],"start_date":"2020-08-10","completion_date":"2021-05-30","last_update_date":"2021-12-30","source_url":"https://clinicaltrials.gov/study/NCT04723160","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:30.378222+00:00","last_seen_at":"2026-09-25T06:20:47.789+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years to 75 Years","comparator":null,"organization":"Visionary Intelligence Ltd.","interventions":["Software assisted imaging diagnosis"],"registry_source":"ClinicalTrials.gov","outcome_measures":["consistent rate of diagnoses — through study completion, an average of 1 year","sensitivity and specificity of software's diagnoses for each diseases — through study completion, an average of 1 year","PPV and NPV of software's diagnoses for each diseases — through study completion, an average of 1 year","full coincidence rate of software's diagnoses — through study completion, an average of 1 year"],"design_description":null,"source_has_results":false},"controlled_terms":["Diabetic Retinopathy","Retinal Vein Occlusion","Retinal Artery Occlusion","Central Serous Chorioretinopathy","Pathologic Myopia","Retinitis Pigmentosa","Epiretinal Membrane","Macular Holes","Nonexudative Age-related Macular Degeneration","Exudative Age Related Macular Degeneration","Suspect Glaucoma","Optic Atrophy","Retinal Detachment","Software assisted imaging diagnosis"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related macular degeneration.","quality_checked_at":"2026-09-25T06:20:59.355028+00:00","duplicate_cluster_key":"id:nct04723160","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2020-08-10 to 2021-05-30","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:20:47.949Z","intervention":["Software assisted imaging diagnosis"],"participants":748,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["consistent rate of diagnoses — through study completion, an average of 1 year","sensitivity and specificity of software's diagnoses for each diseases — through study completion, an average of 1 year","PPV and NPV of software's diagnoses for each diseases — through study completion, an average of 1 year","full coincidence rate of software's diagnoses — through study completion, an average of 1 year"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"vision-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related macular degeneration.","Source terminology contains: age-related macular degeneration.","Abstract supplies longevity context: frail, age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Vision ageing","slug":"vision-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42311","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}