{"type":"trials","record":{"id":42371,"source_id":"clinicaltrials-gov","external_id":"NCT05892731","title":"Study of Cognitive Reserve Disorder Affecting Depression in Aged Related Hearing Loss Via Rest State EEG","brief_summary":"In this study, patients with aged-related hearing loss with depression and without depression were evaluated by audiometry (pure tone audiometry and speech audiometry), cognitive function assessment (MMSE scale for simple mental state test, MoCA Scale for Montreal Cognitive Assessment), and depressive symptoms assessment (GDS-15 and HAMD), resting state EEG. The ananlysis of resting state EEG included power spectral density, traceability analysis, functional connectivity, microstate, clustering coefficient, characteristic path length, characteristic path permeability, and compatibility coefficient. EEG signals were used to explore the activation of brain regions and poor connectivity of brain regions affected by cognitive reserve dissonance on the level of brain imaging. This paper innovatively explores the influence of cognitive reserve dissonance on depressive mood in senile deafness by means of audiological assessment, cognitive function assessment, depression symptom assessment, resting state electroencephalography (EEG) and other technical means. Auditory and cognitive cortical activation, functional connectivity of brain regions, small-world attributes and microstates were analyzed in senile deafness with or without depression at the brain imaging level.","overall_status":"Unknown","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","enrollment":44,"countries":["China"],"start_date":"2023-02-08","completion_date":"2023-12-31","last_update_date":"2023-06-07","source_url":"https://clinicaltrials.gov/study/NCT05892731","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:34.048307+00:00","last_seen_at":"2026-09-25T06:25:04.647+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"55 Years to 89 Years","comparator":null,"organization":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","interventions":["with depression","without depression"],"registry_source":"ClinicalTrials.gov","outcome_measures":["score of Montreal Cognitive Assessment scale — 1 day of enrollment","score of Mini-mental State Examination — 1 day of enrollment","pure tone average — 1 day of enrollment","speech acceptance threshold — 1 day of enrollment","Maximum speech recognition score — 1 day of enrollment","score of 15-item Geriatric Depression Scale — 1 day of enrollment","score of HAMD scale — 1 day of enrollment"],"design_description":null,"source_has_results":false},"controlled_terms":["Age-related Hearing Loss","Cognitive Decline","Depression","with depression","without depression"],"relevance_confidence":62,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Source terminology contains: age-related hearing loss.","quality_checked_at":"2026-09-25T06:25:07.732232+00:00","duplicate_cluster_key":"id:nct05892731","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2023-02-08 to 2023-12-31","comparator":null,"confidence":"structured-source","population":"ALL · 55 Years to 89 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:04.664Z","intervention":["with depression","without depression"],"participants":44,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["score of Montreal Cognitive Assessment scale — 1 day of enrollment","score of Mini-mental State Examination — 1 day of enrollment","pure tone average — 1 day of enrollment","speech acceptance threshold — 1 day of enrollment","Maximum speech recognition score — 1 day of enrollment","score of 15-item Geriatric Depression Scale — 1 day of enrollment","score of HAMD scale — 1 day of enrollment"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"hearing-aging","is_published":true,"match_reasons":["Source terminology contains: age-related hearing loss.","Abstract supplies longevity context: aging.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["controlled terminology","abstract context","study type"],"relevance_score":62,"intelligence_topics":{"name":"Hearing ageing","slug":"hearing-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42371","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}