{"type":"trials","record":{"id":42372,"source_id":"clinicaltrials-gov","external_id":"NCT05796011","title":"PET-CT-based Study of Central Mechanisms of Cortical Metabolism in 18F-FDG and 18F-AV1451 Age-related Deafness","brief_summary":"The participants were recruited from elderly subjects in the age range of 60-85 years and audiological assessments, cognitive function assessments, non-invasive brain imaging, behavioral assessments were collected from the normal control group, the elderly deaf non-hearing group and the elderly deaf hearing group according to the inclusion and exclusion criteria. The project aims to investigate the differences in auditory speech and cognitive function in age-related deafness at the behavioural level, and to investigate the central cortical metabolic mechanisms in age-related deafness at the brain imaging level.","overall_status":"Unknown","phases":[],"study_type":"OBSERVATIONAL","sponsor":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","enrollment":30,"countries":["China"],"start_date":"2022-07-06","completion_date":"2024-01-01","last_update_date":"2023-04-03","source_url":"https://clinicaltrials.gov/study/NCT05796011","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:34.048307+00:00","last_seen_at":"2026-09-25T06:25:04.647+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"50 Years to 85 Years","comparator":null,"organization":"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University","interventions":["hearing aids","without hearing intervention","healthy control"],"registry_source":"ClinicalTrials.gov","outcome_measures":["pure tone average — through study completion, an average of 6 months","Speech recognition score — through study completion, an average of 6 months","MMSE score and grade — through study completion, an average of 6 months","MoCA score and grade — through study completion, an average of 6 months","Otorhinolaryngological diseases and daily life self-assessment questionnaire — through study completion, an average of…","Resting Electroencephalogram — through study completion, an average of 6 months","Functional Near-Infrared Spectoscopy — through study completion, an average of 6 months","Positron emmision tomography — through study completion, an average of 6 months"],"design_description":null,"source_has_results":false},"controlled_terms":["Age-related Hearing Loss","PET-CT","hearing aids","without hearing intervention","healthy control"],"relevance_confidence":70,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Source terminology contains: age-related hearing loss.","quality_checked_at":"2026-09-25T06:25:07.732232+00:00","duplicate_cluster_key":"id:nct05796011","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2022-07-06 to 2024-01-01","comparator":null,"confidence":"structured-source","population":"ALL · 50 Years to 85 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:04.664Z","intervention":["hearing aids","without hearing intervention","healthy control"],"participants":30,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["pure tone average — through study completion, an average of 6 months","Speech recognition score — through study completion, an average of 6 months","MMSE score and grade — through study completion, an average of 6 months","MoCA score and grade — through study completion, an average of 6 months","Otorhinolaryngological diseases and daily life self-assessment questionnaire — through study completion, an average of…","Resting Electroencephalogram — through study completion, an average of 6 months","Functional Near-Infrared Spectoscopy — through study completion, an average of 6 months","Positron emmision tomography — through study completion, an average of 6 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"hearing-aging","is_published":true,"match_reasons":["Source terminology contains: age-related hearing loss.","Title supplies longevity context: age-related.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["controlled terminology","title context","study type"],"relevance_score":70,"intelligence_topics":{"name":"Hearing ageing","slug":"hearing-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42372","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}