{"type":"trials","record":{"id":42393,"source_id":"clinicaltrials-gov","external_id":"NCT03720964","title":"Mitochondrial Genetics of Presbycusis","brief_summary":"The main goal of this study is to identify mitochondrial mutations associated with presbycusis. Patients affected by severe presbycusis and normal hearing controls (according to ISO7029 norm) will be enrolled if satisfying inclusion criteria (aged from 40 to 80 years old) in existing biocollections in the University Hospital of Angers. After DNA extraction, the mitochondrial genome will be sequenced and data in silico analysed.","overall_status":"Unknown","phases":[],"study_type":"OBSERVATIONAL","sponsor":"University Hospital, Angers","enrollment":200,"countries":["France"],"start_date":"2019-04-01","completion_date":"2023-11-01","last_update_date":"2019-04-11","source_url":"https://clinicaltrials.gov/study/NCT03720964","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:34.048307+00:00","last_seen_at":"2026-09-25T06:25:04.647+00:00","metadata":{"sex":"ALL","acronym":"MITOPRES","age_range":"40 Years to 80 Years","comparator":null,"organization":"University Hospital, Angers","interventions":[],"registry_source":"ClinicalTrials.gov","outcome_measures":["identification of mitochondrial mutations associated with presbycusis — the analysis will be conducted at the end of th…","identification of genomic variants associated with presbycusis — the analysis will be conducted at the end of the inclu…","identification of DNA variants associated with environmental susceptibility — the analysis will be conducted at the end…"],"design_description":null,"source_has_results":false},"controlled_terms":["Presbycusis","Age Related Hearing Loss"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: presbycusis.","quality_checked_at":"2026-09-25T06:25:07.732232+00:00","duplicate_cluster_key":"id:nct03720964","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2019-04-01 to 2023-11-01","comparator":null,"confidence":"structured-source","population":"ALL · 40 Years to 80 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:04.668Z","intervention":[],"participants":200,"study_design":"OBSERVATIONAL","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["identification of mitochondrial mutations associated with presbycusis — the analysis will be conducted at the end of th…","identification of genomic variants associated with presbycusis — the analysis will be conducted at the end of the inclu…","identification of DNA variants associated with environmental susceptibility — the analysis will be conducted at the end…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"hearing-aging","is_published":true,"match_reasons":["Title contains controlled term: presbycusis.","Abstract contains controlled term: presbycusis.","Source terminology contains: presbycusis.","Study type is explicitly identified as OBSERVATIONAL."],"matched_fields":["title","abstract","controlled terminology","study type"],"relevance_score":100,"intelligence_topics":{"name":"Hearing ageing","slug":"hearing-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42393","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}