{"type":"trials","record":{"id":42403,"source_id":"clinicaltrials-gov","external_id":"NCT01732289","title":"Genetic Study of Age Related Hearing Loss","brief_summary":"Age-related hearing loss, or presbyacusis, is one of the most common chronically handicapped conditions for the elderly. Many factors including genetics, diet, diseases, drugs, socioeconomic factors and environmental variables were considered to be related to the development of presbyacusis. Evidences have shown that genetic factors play an important role on presbyacusis. However, which genes or their genotypes are associated with presbycusis remain unknown. The aim of this project was to evaluate the association between the genotype of candidate genes and presbyacusis by cross-section and case-control study. In the first stage, the investigators plan to select 700 healthy subjects older than 50 with symmetric, sensorineural hearing loss. The subjects will receive basic otologic examination, pure tone audiometry, questionnaire, and genotype analysis. Because gender and age would affect hearing loss significantly, The investigators will convert the hearing level of all subjects into a gender and age independent Z-score according to ISO 7029 standard. And, The investigators define subjects within higher 30 % of Z-score as the presbyacusis group, and subjects within lower 30% of Z-score as the control group. Finally, The investigators perform Chi square analysis to test the association between genotype of candidate genes or their combinations in both groups, and calculate the odds ratio for presbyacusis between different genotype of candidate genes. Further more, we will evaluate the effect of genotype of candidate genes, environment factors, and gene-environmental interaction on the severity of presbyacusis by multivariate logistic regression. In the second stage, The investigators wish to know the pattern of genotype and hearing level in the high risk families, according to results from the first stage, by description and case-control study. The investigators will perform t-test to evaluate the difference of Z-score in both groups. Besides, The investigators try to evaluate the effects of genotypes, environment factors, and gene-environmental interaction on hearing level in high risk families by multivariate logistic regression.","overall_status":"Completed","phases":["EARLY_PHASE1"],"study_type":"INTERVENTIONAL","sponsor":"National Taiwan University Hospital","enrollment":1000,"countries":["Taiwan"],"start_date":"2008-08-01","completion_date":"2009-07-01","last_update_date":"2012-11-22","source_url":"https://clinicaltrials.gov/study/NCT01732289","editorial_summary":"A registered EARLY_PHASE1 study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:34.048307+00:00","last_seen_at":"2026-09-25T06:25:04.647+00:00","metadata":{"sex":"ALL","acronym":"ARHL","age_range":"45 Months","comparator":null,"organization":"National Taiwan University Hospital","interventions":["genes"],"registry_source":"ClinicalTrials.gov","outcome_measures":["which gene or Single nucleotide polymorphism is related to age related hearing loss — 2008-2009","Which environmental factor(s) or systemic diseases are related to age related hearing loss — 2008-2009"],"design_description":"NON RANDOMIZED · PARALLEL · DIAGNOSTIC · SINGLE","source_has_results":false},"controlled_terms":["Age-related Hearing Loss","Presbycusis","genes"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":35,"publication_state":"published","match_explanation":"Abstract contains controlled term: age-related hearing loss, presbycusis.","quality_checked_at":"2026-09-25T06:25:07.732232+00:00","duplicate_cluster_key":"id:nct01732289","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2008-08-01 to 2009-07-01","comparator":null,"confidence":"structured-source","population":"ALL · 45 Months","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:04.670Z","intervention":["genes"],"participants":1000,"study_design":"NON RANDOMIZED · PARALLEL · DIAGNOSTIC · SINGLE","subject_scope":"Human clinical study registration","evidence_stage":"EARLY_PHASE1","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["which gene or Single nucleotide polymorphism is related to age related hearing loss — 2008-2009","Which environmental factor(s) or systemic diseases are related to age related hearing loss — 2008-2009"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"hearing-aging","is_published":true,"match_reasons":["Abstract contains controlled term: age-related hearing loss, presbycusis.","Source terminology contains: age-related hearing loss, presbycusis.","Abstract supplies longevity context: age-related, elderly.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["abstract","controlled terminology","abstract context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Hearing ageing","slug":"hearing-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42403","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}