{"type":"trials","record":{"id":42495,"source_id":"clinicaltrials-gov","external_id":"NCT02986386","title":"Oral Health for Healthy Cognitive Aging","brief_summary":"Oral health is a critical factor of systemic health, although usually forgotten. A potential relation between cognitive deficits and oral diseases has been suggested. Adult cognitive dysfunctions have a high impact, not only economic, but social and in the family environment. Based on anatomical connectivity between the oral cavity and the central nervous system, the proposed study hypothesizes that masticatory function is a relevant determinant of human cognitive health. The restoration of canonical masticatory function and masticatory training could help to delay the development of such conditions. This project will also test if restoring phasic masticatory function improves the execution of cognitive tasks.","overall_status":"Completed","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Universidad de Granada","enrollment":150,"countries":["Spain"],"start_date":"2016-11-01","completion_date":"2025-12-01","last_update_date":"2026-05-12","source_url":"https://clinicaltrials.gov/study/NCT02986386","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Completed. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:36.493571+00:00","last_seen_at":"2026-09-25T06:25:08.953+00:00","metadata":{"sex":"ALL","acronym":"SOECS","age_range":"18 Years to 75 Years","comparator":null,"organization":"Universidad de Granada","interventions":["Dental occlusion restoration","Orthodontic treatment of malocclusion"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Change of occlusion units — Baseline, 6, 12 and 36 months","Change of cerebral activity — Baseline, 6, 12 and 36 months","Change of cognitive function — Baseline, 6, 12 and 36 months","Change of frame of mind — Baseline, 6, 12 and 36 months","Change of resting brain activity — Baseline, 6, 12 and 36 months"],"design_description":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · NONE","source_has_results":false},"controlled_terms":["Malocclusion","Dementia","Dental occlusion restoration","Orthodontic treatment of malocclusion"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":100,"publication_state":"published","match_explanation":"Title contains controlled term: oral health.","quality_checked_at":"2026-09-25T06:25:14.10514+00:00","duplicate_cluster_key":"id:nct02986386","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2016-11-01 to 2025-12-01","comparator":null,"confidence":"structured-source","population":"ALL · 18 Years to 75 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:08.972Z","intervention":["Dental occlusion restoration","Orthodontic treatment of malocclusion"],"participants":150,"study_design":"RANDOMIZED · PARALLEL · SUPPORTIVE CARE · NONE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Change of occlusion units — Baseline, 6, 12 and 36 months","Change of cerebral activity — Baseline, 6, 12 and 36 months","Change of cognitive function — Baseline, 6, 12 and 36 months","Change of frame of mind — Baseline, 6, 12 and 36 months","Change of resting brain activity — Baseline, 6, 12 and 36 months"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"oral-health-aging","is_published":true,"match_reasons":["Title contains controlled term: oral health.","Abstract contains controlled term: oral health.","Title supplies longevity context: aging.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Oral health and ageing","slug":"oral-health-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42495","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}