{"type":"trials","record":{"id":42790,"source_id":"clinicaltrials-gov","external_id":"NCT03704857","title":"Different Endodontic Treatment Techniques in Postoperative Symptoms, Apical Repair, Longevity of Rehabilitations, and Oral Health-related Quality of Life","brief_summary":"Objective: The objective of this study will be to evaluate the effectiveness of different endodontic treatment techniques in postoperative symptoms, apical repair, longevity of rehabilitations, and oral health-related quality of life. Methods: This prospective, randomized, double-blind clinical study was approved at the Research Ethics Committee (nº 2.353.996) and will consist of a sample of 350 patients who will be attended in the clinics of the Federal University of Fluminense/Institute of Health of Nova Friburgo (UFF/ISNF), in which they will be selected based on eligibility criteria. Patients aged up to 18 years, with teeth with necrotic pulps and radiographic evidence of periapical lesion will be included. These patients will be randomly divided into 8 groups: I (35 patients): unirradicular teeth will be submitted to endodontic treatment with foraminal enlargement, instrumentation with reciprocating rotation, sodium hypochlorite as irrigant, lateral condensation filling with MTA Fillapex; II (35 patients): unirradicular teeth will be submitted to endodontic treatment with foraminal enlargement, instrumentation with reciprocating rotation, sodium hypochlorite as irrigant, photobiomodulation (aPDT and LLLT), lateral condensation filling with MTA Fillapex; III (35 patients): unirradicular teeth will be submitted to endodontic treatment with foraminal enlargement, instrumentation with reciprocating rotation, chlorhexidine as irrigant, lateral condensation filling with MTA fillapex; IV (35 patients): unirradicular teeth will be submitted to endodontic treatment with foraminal enlargement, instrumentation with reciprocating rotation, sodium hypochlorite as irrigant, lateral condensation filling with AH Plus; V (35 patients): unirradicular teeth will be submitted to endodontic treatment with foraminal enlargement, instrumentation with reciprocating rotation, sodium hypochlorite as irrigant, cryotherapy with saline solution, lateral condensation filling with MTA Fillapex; VI (35 patients): unirradicular teeth will be submitted to endodontic treatment with foraminal enlargement, instrumentation with reciprocating rotation, sodium hypochlorite as irrigant, cryotherapy with saline solution, lateral condensation filling with AH Plus; VII (35 patients): unirradicular teeth will be submitted to endodontic treatment with foraminal enlargement, instrumentation with reciprocating rotation, sodium hypochlorite as irrigant, ozone therapy, lateral condensation filling with MTA Fillapex; VIII (35 patients): unirradicular teeth will be submitted to endodontic treatment with foraminal enlargement, instrumentation with reciprocating rotation, sodium hypochlorite as irrigant, ozone therapy, lateral condensation filling with AH Plus; IX (35 patients): molars will be submitted to endodontic treatment with foraminal enlargement, instrumentation with reciprocating rotation, conventional irrigation with sodium hypochlorite, lateral condensation filling with MTA fillapex…","overall_status":"Unknown","phases":[],"study_type":"INTERVENTIONAL","sponsor":"Universidade Federal Fluminense","enrollment":350,"countries":["Brazil"],"start_date":"2017-10-30","completion_date":"2023-03-30","last_update_date":"2022-05-03","source_url":"https://clinicaltrials.gov/study/NCT03704857","editorial_summary":"A registered study indexed because it matched monitored longevity research terms. Registry status: Unknown. Registration does not establish safety or effectiveness.","first_seen_at":"2026-09-25T01:25:36.493571+00:00","last_seen_at":"2026-09-25T06:25:08.953+00:00","metadata":{"sex":"ALL","acronym":null,"age_range":"18 Years","comparator":"Foraminal enlargement with sodium hypochlorite as irrigant; Foraminal enlargement with sodium hypochlorite and AH Plus; Foraminal enlargement with conventional irrigation","organization":"Universidade Federal Fluminense","interventions":["Foraminal Enlargement / Irrigating solutions / Filling materials","Photobiomodulation","Passive ultrasonic irrigation","OHIP-14","Assessment of pain and edema","Assessment of periapical lesion","Longevity of rehabilitations","Cryotherapy","Ozone therapy"],"registry_source":"ClinicalTrials.gov","outcome_measures":["Postoperative pain assessed by visual analog scale after endodontic treatment with enlargement of the apical foramen, i…","Edema assessed by photography after endodontic treatment with enlargement of the apical foramen, in necrotic teeth and…","Radiografic evaluation of apical repair after endodontic treatment with foraminal enlargement. — Radiographs of each to…","Clinical and radiographic evaluation of rehabilations after endodontic treatment with foraminal enlargement. — Definiti…","Oral health-related quality of life assessed by OHIP-14, after endodontic treatment with enlargement of the apical fora…"],"design_description":"RANDOMIZED · SEQUENTIAL · TREATMENT · DOUBLE","source_has_results":false},"controlled_terms":["Endodontically Treated Teeth","Postoperative Pain","Edema","Photochemotherapy","Foraminal Enlargement / Irrigating solutions / Filling materials","Photobiomodulation","Passive ultrasonic irrigation","OHIP-14","Assessment of pain and edema","Assessment of periapical lesion","Longevity of rehabilitations","Cryotherapy","Ozone therapy"],"relevance_confidence":100,"source_quality_score":100,"freshness_score":50,"publication_state":"published","match_explanation":"Title contains controlled term: oral health.","quality_checked_at":"2026-09-25T06:25:14.10514+00:00","duplicate_cluster_key":"id:nct03704857","duplicate_of_id":null,"evidence_snapshot":{"status":"structured","version":1,"duration":"2017-10-30 to 2023-03-30","comparator":"Foraminal enlargement with sodium hypochlorite as irrigant; Foraminal enlargement with sodium hypochlorite and AH Plus; Foraminal enlargement with conventional irrigation","confidence":"structured-source","population":"ALL · 18 Years","provenance":{"duration":"start_date and completion_date","comparator":"registry arm fields","population":"registry eligibility fields","intervention":"registry intervention fields","participants":"enrollment","study_design":"study_type and registry design fields","evidence_stage":"phases","reported_outcome":"not available","outcomes_measured":"registry outcome-measure fields"},"generated_at":"2026-09-25T06:25:09.028Z","intervention":["Foraminal Enlargement / Irrigating solutions / Filling materials","Photobiomodulation","Passive ultrasonic irrigation","OHIP-14","Assessment of pain and edema","Assessment of periapical lesion","Longevity of rehabilitations","Cryotherapy","Ozone therapy"],"participants":350,"study_design":"RANDOMIZED · SEQUENTIAL · TREATMENT · DOUBLE","subject_scope":"Human clinical study registration","evidence_stage":"Phase not reported","safety_context":"Eligibility, adverse-event details, and clinical decisions must be checked in the official registry and with qualified clinicians.","source_support":"Structured registry protocol metadata; no finding-level conclusion is generated.","main_limitation":"This is a study registration. No reusable structured result is available here, so it cannot show whether the intervention worked or was safe.","reported_outcome":null,"outcomes_measured":["Postoperative pain assessed by visual analog scale after endodontic treatment with enlargement of the apical foramen, i…","Edema assessed by photography after endodontic treatment with enlargement of the apical foramen, in necrotic teeth and…","Radiografic evaluation of apical repair after endodontic treatment with foraminal enlargement. — Radiographs of each to…","Clinical and radiographic evaluation of rehabilations after endodontic treatment with foraminal enlargement. — Definiti…","Oral health-related quality of life assessed by OHIP-14, after endodontic treatment with enlargement of the apical fora…"],"regulatory_context":"Trial registration is not regulatory approval and does not establish that an intervention is available."},"clinical_trial_topics":[{"topic_slug":"oral-health-aging","is_published":true,"match_reasons":["Title contains controlled term: oral health.","Abstract contains controlled term: oral health.","Title supplies longevity context: longevity.","Study type is explicitly identified as INTERVENTIONAL."],"matched_fields":["title","abstract","title context","study type"],"relevance_score":100,"intelligence_topics":{"name":"Oral health and ageing","slug":"oral-health-aging"}}],"content_sources":{"name":"ClinicalTrials.gov","homepage_url":"https://clinicaltrials.gov/"}},"canonical_url":"https://www.immortal.life/trials/42790","automation_disclosure":"Generated automatically from cited source metadata. No scientist, clinician, researcher, editor, or human reviewer evaluates this publication before release."}